Lokshina A M, Song C W, Rhee J G, Levitt S H
Int J Hyperthermia. 1985 Apr-Jun;1(2):117-29. doi: 10.3109/02656738509029279.
The changes in blood flow in the skin and muscle of rat by single, two or six heatings, were measured with the radioactive microsphere method. The blood flow rose continuously during the 2 h heatings at temperatures up to 43.0 degrees C and 44.0 degrees C in the skin and muscle, respectively. When heated at higher temperatures, the blood flow increased and then decreased. When heated twice at 43.5 degrees C for 1 h each, the magnitude of the increase in blood flow by the second heating varied depending on the time interval between the two heatings; e.g., the second heating on the 14th day after the first heating induced an increase in blood flow much greater than that by the first heating. When the heating at 43.5 degrees C for 1 h was repeated at intervals of five days, the second and third heatings were as effective as the first heating in increasing the skin blood flow. In the muscle, the second and third heatings were 2-3-fold more effective than the first heating in raising the blood flow. The heat-induced increase in blood flow in the skin and muscle gradually diminished from the fourth heating. The tissue temperature varied considerably during heating with a water bath at a constant temperature, due probably to the changes in blood flow.
采用放射性微球法测定了大鼠皮肤和肌肉单次、两次或六次加热后血流量的变化。在皮肤和肌肉分别加热至43.0℃和44.0℃的2小时内，血流量持续上升。当在更高温度下加热时，血流量先增加后减少。当在43.5℃下每次加热1小时，加热两次时，第二次加热引起的血流量增加幅度取决于两次加热之间的时间间隔；例如，第一次加热后第14天进行的第二次加热引起的血流量增加远大于第一次加热。当每隔五天在43.5℃下加热1小时重复进行时，第二次和第三次加热在增加皮肤血流量方面与第一次加热效果相同。在肌肉中，第二次和第三次加热在增加血流量方面比第一次加热有效2至3倍。从第四次加热开始，加热引起的皮肤和肌肉血流量增加逐渐减弱。在恒温水浴加热过程中，组织温度变化很大，这可能是由于血流量的变化所致。
