Iwata K, Shakil A, Hur W J, Makepeace C M, Griffin R J, Song C W
University of Minnesota Medical School, Department of Therapeutic Radiology, Minneapolis 55455, USA.
Br J Cancer Suppl. 1996 Jul;27:S217-21.
We have studied the feasibility of improving tumour oxygenation with hyperthermia at modest temperatures which are achievable with the use of presently available clinical hyperthermia machines. FSaII tumours grown s.c. in the leg of C3H mice and R3230 AC tumours grown s.c. in the leg of Fischer rats were heated with a water bath and the tumour pO2 was determined with an Eppendorf pO2 histograph. The median pO2 in 7-8 mm diameter control FSaII tumours was 6.5 +/- 0.5 mmHg and it increased to 16.6 +/- 1.1 mmHg when the tumours were heated at 41.5 degrees C for 1 h. The median pO2 in 10 mm diameter control R3230 AC tumours was 3.7 +/- 0.3 mmHg. Heating at 42.5 degrees C for 30 min increased the median pO2 in the R3230 AC tumours to 12.2 +/- 1.8 mmHg. The pO2 in FSaII tumours measured 24 h after heating at 41.5 degrees C for 1 h was still higher than the pO2 before heating. The % frequency of pO2 values lower than 5 mmHg decreased markedly when the tumours were heated at the modest temperatures mentioned above. Modest temperature hyperthermia (MTH) may be an efficient and useful means to improve the oxygenation of human tumours.
我们研究了利用适度温度的热疗来改善肿瘤氧合的可行性，这种适度温度可通过使用目前可用的临床热疗机器实现。将生长于C3H小鼠腿部皮下的FSaII肿瘤以及生长于Fischer大鼠腿部皮下的R3230 AC肿瘤用水浴加热，并用Eppendorf pO2组织血氧仪测定肿瘤的pO2。直径7 - 8毫米的对照FSaII肿瘤的中位pO2为6.5±0.5毫米汞柱，当肿瘤在41.5℃加热1小时后，其升至16.6±1.1毫米汞柱。直径10毫米的对照R3230 AC肿瘤的中位pO2为3.7±0.3毫米汞柱。在42.5℃加热30分钟可使R3230 AC肿瘤的中位pO2升至12.2±1.8毫米汞柱。在41.5℃加热1小时后24小时测量的FSaII肿瘤中的pO2仍高于加热前的pO2。当肿瘤在上述适度温度下加热时，pO2值低于5毫米汞柱的频率百分比显著降低。适度温度热疗（MTH）可能是改善人类肿瘤氧合的一种有效且有用的方法。
