Nicholson G D, Fraser H S, Hassell T A, Bayley A
J Clin Hypertens. 1985 Dec;1(4):295-303.
We evaluated the antihypertensive efficacy of "once-a-day" minoxidil, given in conjunction with a diuretic and sympatholytic, and the effect of this simple regimen on patient compliance. Twenty-one severely hypertensive patients had their existing antihypertensive regimens changed to a single daily dose of chlorthalidone (50-100 mg) and either nadolol (160 mg) or reserpine (.25 mg) for a 3-week period. After stabilization on these two drugs, a single daily dose of minoxidil (2.5 mg) was added to each patient's regimen. Doses were titrated as necessary to achieve diastolic blood pressures of less than 90 mmHg. After 3 and 6 months of maintenance therapy, blood pressures were measured 24 hours after the previous day's dosing to evaluate the persistence of the antihypertensive effect. Twenty-four-hour blood pressure control was achieved on 76% of these occasions, and on at least one occasion in 90% of the patients. In addition, compliance was excellent.
我们评估了与利尿剂和抗交感神经药联合使用的“每日一次”米诺地尔的降压疗效，以及这种简单治疗方案对患者依从性的影响。21名重度高血压患者将其现有的降压方案改为每日单次服用氯噻酮（50 - 100毫克），并联合服用纳多洛尔（160毫克）或利血平（0.25毫克），为期3周。在这两种药物治疗稳定后，在每位患者的治疗方案中添加每日单次剂量的米诺地尔（2.5毫克）。必要时调整剂量，以使舒张压低于90毫米汞柱。维持治疗3个月和6个月后，在前一天给药24小时后测量血压，以评估降压效果的持续性。在这些情况下，76%的时间实现了24小时血压控制，90%的患者至少有一次实现了24小时血压控制。此外，患者的依从性极佳。
