Traub Y M, Boner G, Johnsen A M, McDonald R H, Shapiro A P, Rosenfeld J B
Isr J Med Sci. 1986 May;22(5):360-4.
Minoxidil was given to 16 men with hypertension of various degrees of severity, in conjunction with a diuretic and atenolol. Mean supine and standing blood pressures (BP) on diuretic + atenolol were 172/106 and 162/104 mm Hg, respectively. Minoxidil was added and the dose titrated to lower the diastolic pressure to less than 90 mm Hg. All drugs were taken together once daily. At the end of a maintenance period of 6 months on an average dose of minoxidil of 12 mg (range 2.5 to 20.0 mg), supine BP was 147/87 and standing BP 139/88 mm Hg. Similar BP had been measured throughout the maintenance period, and monitoring of the BP showed that the once daily regimen provided good control for 24 h. A strong correlation was found between the dose of minoxidil necessary to normalize the BP and the mean arterial pressure prior to minoxidil (r = 0.73, P less than 0.005). Serious adverse effects of the drug were observed only in patients receiving doses greater than 10 mg or those with widespread atherosclerosis, or both. We conclude that, when added to a diuretic and a beta-blocker in a once-a-day regimen, minoxidil in a daily dose of less than or equal to 10 mg is effective and well tolerated in mild to moderate hypertension, especially in patients who are free of atherosclerotic complications.
给16名不同严重程度的高血压男性患者服用米诺地尔，并联合使用利尿剂和阿替洛尔。在服用利尿剂+阿替洛尔时，平均仰卧位和站立位血压（BP）分别为172/106和162/104 mmHg。添加米诺地尔并滴定剂量以将舒张压降至90 mmHg以下。所有药物每日一起服用一次。在平均剂量为12 mg（范围为2.5至20.0 mg）的米诺地尔维持治疗6个月结束时，仰卧位血压为147/87，站立位血压为139/88 mmHg。在整个维持治疗期间测量到类似的血压，并且血压监测表明每日一次的给药方案可提供24小时的良好控制。发现使血压正常化所需的米诺地尔剂量与服用米诺地尔之前的平均动脉压之间存在强相关性（r = 0.73，P<0.005）。仅在接受剂量大于10 mg的患者或患有广泛动脉粥样硬化的患者或两者兼有的患者中观察到该药物的严重不良反应。我们得出结论，当以每日一次的方案添加到利尿剂和β受体阻滞剂中时，每日剂量小于或等于10 mg的米诺地尔对轻度至中度高血压有效且耐受性良好，尤其是在没有动脉粥样硬化并发症的患者中。
