Department of Reproductive Medicine, Huzhou Maternity & Child Health Care Hospital, Huzhou, 313000, Zhejiang Province, China.
Department of Obstetrics and Gynecology, Huzhou Maternity & Child Health Care Hospital, Huzhou, 313000, Zhejiang Province, China.
Reprod Sci. 2024 Aug;31(8):2209-2218. doi: 10.1007/s43032-024-01476-0. Epub 2024 Feb 16.
Observational investigations recommend that mineral supplements were associated with a higher risk of polycystic ovary syndrome (PCOS) and its risk factors (insulin resistance, hyperandrogenism, and obesity), but the relationship with risk of PCOS, hyperandrogenism, obesity, and insulin resistance was unclear. This study was to investigate the potential causal impact of genetically predicted levels of magnesium (Mg), calcium (Ca), selenium (Se), zinc (Zn), iron (Fe), and omega-3 (ω-3) on polycystic ovary syndrome (PCOS) and its associated risk factors. A two-sample Mendelian randomization (MR) analysis was conducted. The genetic variations obtained from GWAS of individuals with European ancestry were found to be associated with the genetically predicted levels of Ca, Mg, Zn, Se, Fe, or ω-3. The data obtained from the FinnGen Consortium and MAGIC were utilized for the outcome of GWAS. The study found that there was a correlation between genetically predicted higher levels of Se and a reduced risk of insulin resistance, with a decrease of 2.2% according to random-effect IVW (OR 0.978, 95% CI 0.960-0.996, p = 0.015). The association between genetically determined mineral levels and PCOS was found to be limited, with an odds ratio (OR) ranging from 0.875 (95% CI: 0.637-1.202, p value = 0.411) for Ca. Limited scientific proof was found for the efficacy of other genetically determined mineral levels on hyperandrogenism, obesity, and insulin resistance. These findings suggested a causal relationship between genetically predicted higher levels of Se and a reduced risk of insulin resistance. Nonetheless, there is limited evidence supporting a causal association between various genetically determined mineral levels and the risk factors associated with PCOS.
观察性研究表明，矿物质补充剂与多囊卵巢综合征（PCOS）及其风险因素（胰岛素抵抗、高雄激素血症和肥胖）的发生风险增加相关，但矿物质补充剂与 PCOS、高雄激素血症、肥胖和胰岛素抵抗发生风险的关系尚不清楚。本研究旨在探讨遗传预测水平的镁（Mg）、钙（Ca）、硒（Se）、锌（Zn）、铁（Fe）和 ω-3（ω-3）对多囊卵巢综合征（PCOS）及其相关风险因素的潜在因果影响。进行了两样本 Mendelian 随机化（MR）分析。从具有欧洲血统的个体的 GWAS 中获得的遗传变异与遗传预测的 Ca、Mg、Zn、Se、Fe 或 ω-3 水平相关。来自 FinnGen 联盟和 MAGIC 的数据用于 GWAS 的结果。研究发现，遗传预测的 Se 水平较高与胰岛素抵抗风险降低之间存在相关性，根据随机效应 IVW，OR 降低 2.2%（0.978，95%CI 0.960-0.996，p=0.015）。遗传决定的矿物质水平与 PCOS 之间的关联被发现是有限的，OR 范围为 Ca 为 0.875（95%CI：0.637-1.202，p 值=0.411）。对于其他遗传决定的矿物质水平对高雄激素血症、肥胖和胰岛素抵抗的疗效，证据有限。这些发现表明遗传预测的 Se 水平较高与胰岛素抵抗风险降低之间存在因果关系。然而，目前仅有有限的证据支持各种遗传决定的矿物质水平与 PCOS 相关风险因素之间存在因果关联。
