睡眠质量对戒烟尝试期间饮酒复发的影响。
Influence of sleep quality on lapse to alcohol use during a quit attempt.
机构信息
Department of Psychology, University of California, Los Angeles, 1285 Franz Hall, Box 51563, Los Angeles, CA 90095-1563, United States.
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, 757 Westwood Plaza #4, Los Angeles, CA 90095, United States.
出版信息
Alcohol Alcohol. 2024 Jan 17;59(2). doi: 10.1093/alcalc/agae009.
AIMS
Sleep problems are common among individuals with alcohol use disorder (AUD) and is often associated with a heightened relapse risk. The present study examines the relationship between sleep and alcohol use among individuals with current AUD during a 6-day quit attempt as part of a medication study.
METHODS
The current study is a secondary analysis of a medication trial for individuals with AUD. Individuals with AUD (N = 53, 26 females) were randomized to active medication or matched placebo. Randomized participants completed a week-long medication titration (Days 1-7). Following the titration period, participants attended an in-person visit (Day 8) to begin a 6-day quit attempt. During the quit attempt, participants completed daily diary assessments to report on previous day alcohol consumption, sleep quality, and alcohol craving. In the present study, medication condition was controlled for in all models.
RESULTS
Baseline global sleep quality was not a significant predictor of drinks per drinking day (P = 0.72) or percent days abstinent (P = 0.16) during the 6-day practice quit attempt. Daily diary analyses found that greater sleep quality was associated with higher next-day drinks per drinking day (b = 0.198, P = 0.029). In contrast, participants reported worse sleep quality following nights of greater alcohol intake, albeit at a trend-level (b = -0.12, P = 0.053).
CONCLUSIONS
These results suggest that better sleep quality was a risk factor for drinking during the 6-day quit period, such that better sleep may be associated with increased craving for alcohol and alcohol use the next day. These findings are limited to the early abstinence period and should be considered in studies exploring longer periods of abstinence.
目的
睡眠问题在患有酒精使用障碍（AUD）的个体中很常见，并且通常与更高的复发风险相关。本研究在药物研究的一部分中，在为期 6 天的戒烟尝试期间，检查了当前患有 AUD 的个体的睡眠与酒精使用之间的关系。
方法
本研究是 AUD 药物试验的二次分析。将 AUD 患者（N=53，女性 26 名）随机分配至活性药物或匹配的安慰剂。随机分组参与者完成了为期一周的药物滴定（第 1-7 天）。滴定期结束后，参与者参加了一次面对面的就诊（第 8 天），开始进行为期 6 天的戒烟尝试。在戒烟尝试期间，参与者完成了每日日记评估，以报告前一天的酒精摄入量、睡眠质量和酒精渴求。在本研究中，所有模型均控制了药物条件。
结果
基线总体睡眠质量不是第 6 天戒烟尝试期间每日饮酒量（P=0.72）或无饮酒日的百分比（P=0.16）的显著预测因素。每日日记分析发现，睡眠质量越好，下一天的饮酒量越高（b=0.198，P=0.029）。相比之下，尽管呈趋势性（b=-0.12，P=0.053），但参与者报告在饮酒量较大的夜晚睡眠质量较差。
结论
这些结果表明，更好的睡眠质量是戒烟 6 天期间饮酒的危险因素，因此更好的睡眠可能与第二天对酒精的渴望和饮酒增加有关。这些发现仅限于早期禁欲期，在探索更长禁欲期的研究中应予以考虑。
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