Bhowmik Rintu, Roy Mithun
Department of Chemistry, National Institute of Technology Manipur, Langol, 795004, Imphal West, Manipur, India.
Department of Chemistry, National Institute of Technology Manipur, Langol, 795004, Imphal West, Manipur, India.
Eur J Med Chem. 2024 Mar 15;268:116217. doi: 10.1016/j.ejmech.2024.116217. Epub 2024 Feb 10.
Nitric oxide (NO) is an important biological messenger as well as a signaling molecule that participates in a broad range of physiological events and therapeutic applications in biological systems. However, due to its very short half-life in physiological conditions, its therapeutic applications are restricted. Efforts have been made to develop an enormous number of NO-releasing molecules (NORMs) and motifs for NO delivery to the target tissues. These NORMs involve organic nitrate, nitrite, nitro compounds, transition metal nitrosyls, and several nanomaterials. The controlled release of NO from these NORMs to the specific site requires several external stimuli like light, sound, pH, heat, enzyme, etc. Herein, we have provided a comprehensive review of the biochemistry of nitric oxide, recent advancements in NO-releasing materials with the appropriate stimuli of NO release, and their biomedical applications in cancer and other disease control.
一氧化氮（NO）是一种重要的生物信使以及信号分子，它参与生物系统中的广泛生理事件和治疗应用。然而，由于其在生理条件下的半衰期非常短，其治疗应用受到限制。人们已经做出努力来开发大量用于将NO递送至靶组织的一氧化氮释放分子（NORMs）和基序。这些NORMs包括有机硝酸盐、亚硝酸盐、硝基化合物、过渡金属亚硝酰基以及几种纳米材料。要使这些NORMs将NO可控地释放到特定部位，需要光、声、pH值、热、酶等几种外部刺激。在此，我们全面综述了一氧化氮的生物化学、具有适当NO释放刺激的NO释放材料的最新进展及其在癌症和其他疾病控制中的生物医学应用。
