Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Wuxi 214122, Jiangsu Province, People's Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu Province, People's Republic of China; Collaborative Innovation Center for Food Safety and Quality Control, Jiangnan University, Wuxi, 214122, Jiangsu Province, People's Republic of China.
Carbohydr Polym. 2024 Apr 15;330:121825. doi: 10.1016/j.carbpol.2024.121825. Epub 2024 Jan 19.
Butyrylated starch is produced by the esterification of hydroxyl groups in starch with butyryl groups, which improves the structural diversity of starch and expands its function and biological activity. The paper summarizes the structural properties and digestive properties, fermentation properties, and biological activities of butyrylated starch and describes the conformational relationships generated by the butyryl groups to reveal the underlying mechanisms. The butyryl groups replace the hydroxyl groups in starch and break the hydrogen bonds, which consequently changes the molecular, crystal, and granular structures of starch, while the starch structure also affects the distribution of the butyryl groups. Binding to the butyryl groups gives starch efficacy in resisting digestion, lowering the glycaemic index, releasing butyric acid in the colon, and regulating intestinal flora and metabolites. Relationships between starch structural parameters and butyric acid production and intestinal flora were also concluded to provide guidance for the rational design of butyrylated starch to improve efficacy. Moreover, based on its digestive and fermentation properties, butyrylated starch has exhibited good therapeutic efficacy for intestinal diseases, diabetes, polycystic ovary syndrome, and chronic restraint stress-induced abnormalities. This review provides a valuable reference for butyrylated starch advancement and utilization.
丁酰化淀粉是通过将淀粉中的羟基与丁酰基酯化而生产的，这提高了淀粉的结构多样性，并扩展了其功能和生物活性。本文总结了丁酰化淀粉的结构特性和消化特性、发酵特性和生物活性，并描述了丁酰基产生的构象关系，以揭示潜在的机制。丁酰基取代了淀粉中的羟基并打破了氢键，这导致了淀粉的分子、晶体和颗粒结构发生变化，而淀粉结构也影响了丁酰基的分布。与丁酰基的结合使淀粉具有抵抗消化、降低血糖指数、在结肠中释放丁酸以及调节肠道菌群和代谢物的功效。还总结了淀粉结构参数与丁酸产生和肠道菌群之间的关系，为合理设计丁酰化淀粉以提高功效提供了指导。此外，基于其消化和发酵特性，丁酰化淀粉已显示出对肠道疾病、糖尿病、多囊卵巢综合征和慢性束缚应激诱导的异常的良好治疗效果。本文综述为丁酰化淀粉的发展和利用提供了有价值的参考。
