左手性 RNA 四链体指导基因沉默。
A left-handed RNA quadruplex directs gene silencing.
机构信息
Department of Biochemistry, University of Wisconsin-Madison, Madison, WI, USA.
出版信息
Trends Biochem Sci. 2024 May;49(5):387-390. doi: 10.1016/j.tibs.2024.01.009. Epub 2024 Feb 16.
Abstract
Poly(UG) or 'pUG' dinucleotide repeats direct gene silencing in Caenorhabditis elegans by adopting an unusual quadruplex structure. Humans have thousands of pUG sequences and proteins that interact with them. The pUG fold reveals new aspects of gene regulation and RNA folding, highlighting how a simple sequence can encode a complex structure.
摘要
聚（尿嘧啶-鸟嘌呤）或 'pUG' 二核苷酸重复通过采用一种不寻常的四链结构在秀丽隐杆线虫中指导基因沉默。人类有数以千计的 pUG 序列和与它们相互作用的蛋白质。pUG 折叠揭示了基因调控和 RNA 折叠的新方面，突出了简单的序列如何编码复杂的结构。
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引用本文的文献
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