Key Laboratory of Basic and Application Research of Beiyao (Heilongjiang University of Chinese Medicine), Ministry of Education, Harbin, Heilongjiang, China (mainland).
Institute of Polygenic Disease, Qiqihar Medical University, Qiqihar, Heilongjiang, China (mainland).
Med Sci Monit. 2024 Feb 19;30:e942783. doi: 10.12659/MSM.942783.
Resibufogenin (RBG), a significant bufadienolide compound found in the traditional Chinese medicine Chansu, has garnered increasing attention in recent years for its wide range of pharmacological effects. This compound has shown promising potential in various therapeutic areas, including oncology, cardiology, and respiratory medicine. Among its notable properties, the anticancer effects of RBG are particularly striking, positioning it as a potential candidate for innovative cancer treatments. The mechanism of action of RBG is diverse, impacting various cellular processes. Its anticancer efficacy has been observed in different types of cancer cells, where it induces apoptosis and inhibits cell proliferation. Beyond its oncological applications, RBG also demonstrates substantial anti-inflammatory and antiviral activities. These properties suggest its utility in managing chronic inflammatory disorders and viral infections, respectively. The compound's cardiotonic effects are also noteworthy, providing potential benefits in cardiovascular health, particularly in heart failure management. Additionally, RBG has shown effectiveness in blood pressure regulation and respiratory function improvement, making it a versatile agent in the treatment of hypertension and respiratory disorders. However, despite these promising aspects, systematic reviews focusing specifically on RBG are limited. This article aims to address this gap by comprehensively reviewing RBG's origin, physiological, and pharmacological effects. The review will serve as a crucial reference for clinicians and researchers interested in the therapeutic applications of RBG, highlighting its potential in various medical domains. By synthesizing current research findings, this review will facilitate a deeper understanding of RBG's role in medicine and encourage further investigation into its clinical uses.
Resibufogenin (RBG)，一种存在于中药蟾酥中的重要蟾蜍内酯化合物，近年来因其广泛的药理作用而受到越来越多的关注。这种化合物在肿瘤学、心脏病学和呼吸医学等多个治疗领域显示出了有前途的潜力。在其显著的特性中，RBG 的抗癌作用尤为引人注目，使其成为创新癌症治疗的潜在候选药物。RBG 的作用机制多种多样，影响着各种细胞过程。它在不同类型的癌细胞中表现出抗癌功效，诱导细胞凋亡并抑制细胞增殖。除了在肿瘤学上的应用外，RBG 还表现出显著的抗炎和抗病毒活性。这些特性表明它在分别治疗慢性炎症性疾病和病毒感染方面具有应用价值。该化合物的强心作用也值得注意，为心血管健康提供了潜在的益处，特别是在心衰管理方面。此外，RBG 还在调节血压和改善呼吸功能方面显示出有效性，使其成为治疗高血压和呼吸障碍的多功能药物。然而，尽管有这些有希望的方面，但专门针对 RBG 的系统评价仍然有限。本文旨在通过全面综述 RBG 的来源、生理和药理作用来填补这一空白。该综述将为对 RBG 治疗应用感兴趣的临床医生和研究人员提供重要参考，突出其在各个医学领域的潜在应用。通过综合当前的研究结果，本综述将促进对 RBG 在医学中的作用的更深入理解，并鼓励进一步研究其临床用途。
