Zheng Ya, Feng Na, Li Canglin, Li Zuoqiang
The Second Gastroenterology Department, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, China.
Department of Rehabilitation Medicine, Linyi Maternal and Child Health Center Hospital, Linyi, Shandong, China.
Front Pharmacol. 2025 Apr 24;16:1565332. doi: 10.3389/fphar.2025.1565332. eCollection 2025.
As a highly prevalent gastrointestinal malignant tumor, colorectal cancer poses a serious challenge in terms of increasing morbidity and mortality and late diagnosis due to the invisibility of the disease. Although existing therapies are diverse but limited in efficacy, the mechanism of programmed cell death (PCD) has become a focus of research due to its central role in maintaining body homeostasis and regulating tumor progression. Multimodal cell death pathways, such as apoptosis, autophagy, pyroptosis and ferroptosis, have shown unique advantages in inhibiting the proliferation and migration of colorectal cancer cells and enhancing the sensitivity to chemotherapy by responding to internal and external environmental stimuli. In recent years, natural products have risen to prominence by virtue of their multi-target synergistic effects and chemo-sensitizing properties, and have opened up a new direction for colorectal cancer treatment by precisely regulating the PCD pathway. In this paper, we searched PubMed, Web of Science and CNKI databases for relevant studies in the last 10 years using the keywords (Colorectal cancer) and (programmed cell death) and natural products. This work retrieved 59 studies (55 from the past 5 years and 4 from the past 10 years) to reveal the mechanism of action of natural products targeting PCD, aiming to provide theoretical support and practical guidance for the optimization of clinical therapeutic strategies and the development of innovative drugs.
作为一种高度常见的胃肠道恶性肿瘤，由于其隐匿性，结直肠癌在发病率和死亡率上升以及诊断延迟方面构成了严峻挑战。尽管现有疗法多种多样，但疗效有限，程序性细胞死亡（PCD）机制因其在维持机体稳态和调节肿瘤进展中的核心作用而成为研究热点。多模态细胞死亡途径，如凋亡、自噬、焦亡和铁死亡，通过响应内部和外部环境刺激，在抑制结直肠癌细胞增殖和迁移以及增强化疗敏感性方面显示出独特优势。近年来，天然产物凭借其多靶点协同效应和化疗增敏特性崭露头角，并通过精确调节PCD途径为结直肠癌治疗开辟了新方向。在本文中，我们使用关键词（结直肠癌）、（程序性细胞死亡）和天然产物在PubMed、Web of Science和CNKI数据库中检索了过去10年的相关研究。这项工作检索到59项研究（55项来自过去5年，4项来自过去10年），以揭示天然产物靶向PCD的作用机制，旨在为优化临床治疗策略和开发创新药物提供理论支持和实践指导。
