Heldmaier G, Seidl K
J Comp Physiol B. 1985;155(6):679-84. doi: 10.1007/BF00694581.
In Djungarian hamsters the cold-induced thermoregulatory heat production was preceded and accompanied by an increase in the plasma level of free fatty acids. In warm-acclimated hamsters this increase was found more pronounced (0.85 to 1.48 mM) than in cold-acclimated hamsters (0.64 to 0.88 mM). Noradrenaline-induced thermogenesis at thermoneutrality provoked a similar increase in the free fatty acid level. Inhibition of nonshivering thermogenesis during cold exposure by propranolol abolished the increase in free fatty acids completely. The surgical removal of brown adipose tissue proportionately reduced the increase in free fatty acids. This indicates that the rise in plasma free fatty acids is functionally related to nonshivering thermogenesis and originates from brown adipose tissue.
在西伯利亚仓鼠中，寒冷诱导的体温调节性产热之前和过程中，血浆游离脂肪酸水平会升高。在温暖适应的仓鼠中，这种升高（从0.85毫摩尔升至1.48毫摩尔）比寒冷适应的仓鼠（从0.64毫摩尔升至0.88毫摩尔）更为明显。在热中性条件下，去甲肾上腺素诱导的产热也会引起游离脂肪酸水平类似的升高。普萘洛尔抑制寒冷暴露期间的非寒战产热后，游离脂肪酸的升高完全消失。手术切除褐色脂肪组织会相应减少游离脂肪酸的升高。这表明血浆游离脂肪酸的升高在功能上与非寒战产热相关，且源于褐色脂肪组织。
