Yuan Chao, An Tianfeng, Li Xinlong, Zou Jiao, Lin Zhan, Gu Jiale, Hu Ruixia, Fang Zhongze
Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, China.
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin Medical University, Tianjin, China.
Front Microbiol. 2024 Feb 2;14:1272636. doi: 10.3389/fmicb.2023.1272636. eCollection 2023.
, the most critical clinical pathogen of the genus , has been identified as a causative agent of numerous harmful infections. Additionally, demonstrates adaptability to extreme environmental conditions, such as those found in drinking water. In this study, we conducted a comprehensive genomic analysis to investigate the genomic characteristics related to potential pathogenicity and adaptive evolution in drinking water environments of . Through phylogenetic analysis and population genetic analysis, we divided into five Groups, two of which were associated with drinking water environments. The open pan-genome with a large and flexible gene repertoire indicated a high genetic plasticity. Significant differences in functional enrichment were observed between the core- and pan-genome of different groups. Diverse mobile genetic elements (MGEs), extensive genomic rearrangements, and horizontal gene transfer (HGT) events played a crucial role in generating genetic diversity. In drinking water environments, exhibited strong adaptability, and the acquisition of specific adaptive genes was potentially facilitated by genomic islands (GIs) and HGT. Furthermore, environmental pressures drove the adaptive evolution of , leading to the accumulation of unique mutations in key genes. These mutations may have a significant impact on various physiological functions, particularly carbon metabolism and energy metabolism. The presence of virulence-related elements associated with macromolecular secretion systems, virulence factors, and antimicrobial resistance indicated the potential pathogenicity of , making it capable of causing multiple nosocomial infections. This study provides comprehensive insights into the potential pathogenicity and adaptive evolution of in drinking water environments from a genomic perspective.
[该属最关键的临床病原体]已被确定为多种有害感染的病原体。此外，[该病原体]表现出对极端环境条件的适应性，例如在饮用水中发现的那些条件。在本研究中，我们进行了全面的基因组分析，以研究与[该病原体]在饮用水环境中的潜在致病性和适应性进化相关的基因组特征。通过系统发育分析和群体遗传分析，我们将[该病原体]分为五组，其中两组与饮用水环境相关。具有庞大且灵活基因库的开放泛基因组表明其具有高遗传可塑性。不同组的核心基因组和泛基因组在功能富集方面存在显著差异。多样的移动遗传元件（MGEs）、广泛的基因组重排和水平基因转移（HGT）事件在产生遗传多样性方面发挥了关键作用。在饮用水环境中，[该病原体]表现出很强的适应性，基因组岛（GIs）和HGT可能促进了特定适应性基因的获得。此外，环境压力推动了[该病原体]的适应性进化，导致关键基因中独特突变的积累。这些突变可能对各种生理功能产生重大影响，特别是碳代谢和能量代谢。与大分子分泌系统、毒力因子和抗菌抗性相关的毒力相关元件的存在表明了[该病原体]的潜在致病性，使其能够引起多种医院感染。本研究从基因组角度全面深入地了解了[该病原体]在饮用水环境中的潜在致病性和适应性进化。
