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基于珊瑚状中空金纳米球的高效光热传感器用于磺胺类药物的灵敏检测

Efficient Photothermal Sensor Based on Coral-Like Hollow Gold Nanospheres for the Sensitive Detection of Sulfonamides.

作者信息

Xiao Xiaoyue, Yu Sha, Zhang Gan, Chen Zongyou, Hu Hong, Lai Xiaocui, Liu Daofeng, Lai Weihua

机构信息

State Key Laboratory of Food Science and Resources, Nanchang University, 235 East Nanjing Road, Nanchang, 330047, China.

Jiangxi Province Key Laboratory of Diagnosing and Tracing of Foodborne Disease, Jiangxi Province Centre for Disease Control and Prevention, 555 East Beijing Road, Nanchang, 330029, China.

出版信息

Small. 2024 Jul;20(28):e2307764. doi: 10.1002/smll.202307764. Epub 2024 Feb 19.

Abstract

Gold nanoparticles (AuNPs), universally regarded as colorimetric signal reporters, are widely employed in lateral flow immunoassays (LFIAs). However, it is difficult for AuNPs-LFIA to achieve a wide range and sensitive detection. Herein, novel coral-like hollow gold nanospheres (CHGNPs) are synthesized. The growth of gold nanospheres can be regulated to obtain a multibranched and hollow construction. The obtained CHGNPs possess intense broadband absorption across the visible to near-infrared region, exhibiting a high molar extinction coefficient of 14.65 × 10 M cm and a photothermal conversion efficiency of 79.75%. Thus, the photothermal/colorimetric dual-readout LFIA is developed based on CHGNPs (CHGNPs-PT-LFIA and CHGNPs-CM-LFIA) to effectively improve the detection sensitivity and broaden the detection range in regard to sulfonamides (SAs). The limits of detection of the CHGNPs-PT-LFIA and CHGNPs-CM-LFIA reached 1.9 and 2.8 pg mL for the quantitative detection of sulfaquinoxaline, respectively, which are 6.3-fold and 4.3-fold lower than that of the AuNPs-LFIA. Meanwhile, the CHGNPs-PT-LFIA broadened the detection range to three orders of magnitude, which ranged from 2.5 to 5000 pg mL. The synthesized photothermal CHGNPs have been proven effective in improving the performance of the LFIA and provide a potential option for the construction of sensing platforms.

摘要

金纳米颗粒(AuNPs)被普遍视为比色信号报告分子,广泛应用于侧向流动免疫分析(LFIAs)中。然而,基于AuNPs的LFIAs难以实现宽范围且灵敏的检测。在此,合成了新型珊瑚状中空金纳米球(CHGNPs)。金纳米球的生长可得到调控,从而获得多分支且中空的结构。所制备的CHGNPs在可见光至近红外区域具有强烈的宽带吸收,摩尔消光系数高达14.65×10 M cm,光热转换效率为79.75%。因此,基于CHGNPs开发了光热/比色双读出LFIAs(CHGNPs-PT-LFIA和CHGNPs-CM-LFIA),以有效提高对磺胺类药物(SAs)的检测灵敏度并拓宽检测范围。CHGNPs-PT-LFIA和CHGNPs-CM-LFIA对磺胺喹恶啉定量检测的检测限分别达到1.9和2.8 pg mL,分别比AuNPs-LFIA低6.3倍和4.3倍。同时,CHGNPs-PT-LFIA将检测范围拓宽至三个数量级,范围为2.5至5000 pg mL。已证明合成的光热CHGNPs在改善LFIAs性能方面有效,并为传感平台的构建提供了一种潜在选择。

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