Henan Province Key Laboratory of New Opto-Electronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang 455000, China.
College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China.
Sensors (Basel). 2024 Oct 6;24(19):6458. doi: 10.3390/s24196458.
Developing powerful immunoassays for sensitive and real-time detection of targets has always been a challenging task. Due to their advantages of direct readout, controllable sensing, and low background interference, photothermal immunoassays have become a type of new technology that can be used for various applications such as disease diagnosis, environmental monitoring, and food safety. By modification with antibodies, photothermal materials can induce temperature changes by converting light energy into heat, thereby reporting specific target recognition events. This article reviews the design and application of photothermal immunoassays based on different photothermal materials, including noble metal nanomaterials, carbon-based nanomaterials, two-dimensional nanomaterials, metal oxide and sulfide nanomaterials, Prussian blue nanoparticles, small organic molecules, polymers, etc. It pays special attention to the role of photothermal materials and the working principle of various immunoassays. Additionally, the challenges and prospects for future development of photothermal immunoassays are briefly discussed.
开发用于敏感和实时检测目标的强大免疫分析一直是一项具有挑战性的任务。由于光热免疫分析具有直接读出、可控传感和低背景干扰等优点，已成为一种新型技术，可用于疾病诊断、环境监测和食品安全等各种应用。通过与抗体修饰，光热材料可以将光能转化为热能，从而引起温度变化，从而报告特定的目标识别事件。本文综述了基于不同光热材料的光热免疫分析的设计和应用，包括贵金属纳米材料、碳基纳米材料、二维纳米材料、金属氧化物和硫化物纳米材料、普鲁士蓝纳米粒子、小分子、聚合物等。特别关注了光热材料的作用和各种免疫分析的工作原理。此外，还简要讨论了光热免疫分析未来发展的挑战和前景。
