H. E. J. Research Institute of Chemistry, International Center for Chemical & Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
Department of Biochemistry, Multi-Disciplinary Research Laboratory, Bahria University Medical & Dental College, Karachi - 74400, Pakistan.
Future Med Chem. 2024 Mar;16(6):497-511. doi: 10.4155/fmc-2023-0213. Epub 2024 Feb 19.
Unsymmetrical thioureas were synthesized and then characterized by various spectroscopy techniques such as UV, IR, fast atom bombardment (FAB)-MS, high-resolution FAB-MS, H-NMR and C-NMR. Synthetic compounds were tested for their ability for antioxidant, lipoxygenase and xanthine oxidase activities. Compounds , , , and exhibited strong antioxidant potential, whereas compounds , , , and showed good to moderate lipoxygenase activity. Ten compounds demonstrated moderate xanthine oxidase inhibition. Compound displayed the highest potency among the series, exhibiting good antioxidant, lipoxygenase and xanthine oxidase activities. Theoretical calculations using density functional theory and molecular docking studies supported the experimental findings, indicating the potential of the synthesized compounds as potent antioxidants, lipoxygenases and xanthine oxidase agents.
不对称硫脲被合成，并通过各种光谱技术如紫外、红外、快原子轰击（FAB）-MS、高分辨率 FAB-MS、H-NMR 和 C-NMR 进行了表征。合成化合物被测试了其抗氧化、脂氧合酶和黄嘌呤氧化酶活性的能力。化合物 、 、 、 和 表现出较强的抗氧化潜力，而化合物 、 、 、 和 表现出良好到中等的脂氧合酶活性。十种化合物显示出中等的黄嘌呤氧化酶抑制作用。化合物 在该系列中表现出最高的活性，表现出良好的抗氧化、脂氧合酶和黄嘌呤氧化酶活性。使用密度泛函理论和分子对接研究的理论计算支持了实验结果，表明合成化合物作为有效的抗氧化剂、脂氧合酶和黄嘌呤氧化酶抑制剂的潜力。
