Brownfoot Fiona, Rolnik Daniel Lorber
Mercy Hospital for Women, Heidelberg, Victoria, Australia; Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia.
Women's and Newborn, Monash Health, Clayton, Victoria, Australia; Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.
Best Pract Res Clin Obstet Gynaecol. 2024 Mar;93:102481. doi: 10.1016/j.bpobgyn.2024.102481. Epub 2024 Feb 15.
Preeclampsia is a relatively common pregnancy complication and constitutes a major cause of morbidity and mortality for mothers and children worldwide. It disproportionally affects low-resource countries. Appropriate identification of individuals at increased risk and prevention of the disease and its complications remain healthcare and research priorities, and the investigation of potential interventions to prevent preeclampsia has driven much of the obstetric research in recent decades. In this article, we review the scientific literature on the topic, highlighting established benefits and remaining questions regarding different non-pharmacological and pharmacological strategies, including exercise, the timing of birth, aspirin and calcium use, among others, as well as potential novel therapies under investigation.
子痫前期是一种相对常见的妊娠并发症，是全球范围内母婴发病和死亡的主要原因。它对资源匮乏国家的影响尤为严重。准确识别高危个体并预防该疾病及其并发症仍是医疗保健和研究的重点，近几十年来，对预防子痫前期潜在干预措施的研究推动了许多产科研究。在本文中，我们回顾了关于该主题的科学文献，重点介绍了不同非药物和药物策略（包括运动、分娩时机、阿司匹林和钙的使用等）已确立的益处和尚存的问题，以及正在研究的潜在新疗法。
