Yuzuncu Yil University, Faculty of Medicine, Gynecology and Obstetrics Clinic - Van, Turkey.
Zeynep Kamil Women and Children Research Hospital - İstanbul, Turkey.
Rev Assoc Med Bras (1992). 2024 Aug 16;70(8):e20240152. doi: 10.1590/1806-9282.20240152. eCollection 2024.
The aim of this study was to evaluate mitofusin-2 levels and fetal Doppler ultrasonography effects in patients with severe preeclampsia.
This single-center case-control study was conducted in the gynecology service of the university hospital in Van. A total of 90 pregnant women aged 18-40 years were included in the study. Of these, 30 are normal, 30 have mild preeclampsia, and 30 are pregnant with severe preeclampsia. In this study, especially in severe preeclampsia patients, serum mitofusin-2 levels and important fetal Doppler flows such as uterine arterial pressure, umbilical arterial pressure, and 1st and 5th minute Apgar scores, birth weight, and the relationship between postnatal outcomes such as week of birth and the number of patients in the neonatal intensive care unit were investigated.
There was a significant difference between the three groups in terms of mitofusin-2 levels, which was the highest in the group (p<0.05). Maternal serum mitofusin-2 levels were positively correlated with uterine arterial pressure (r=0.543, p=0.007), umbilical arterial pressure (r=0.238, p=0.008), diastolic blood pressure, and systolic blood pressure (p<0.001). Receiver operating characteristic curve of mitofusin-2 in predicting preeclampsia is as follows: optimal cutoff 1.6 ng/mL; area under the curve: 0.861; 95%CI: 0.786-0.917; sensitivity: 83.9%; and specificity: 70.0%, (p≤0.001). A one-unit increase in mitofusin-2 resulted in a statistically significant 4.21-fold increase in preeclampsia risk.
This study recommends the use of mitofusin-2 together with fetal Doppler ultrasound findings as a reliable indicator of preeclampsia severity.
本研究旨在评估线粒体融合蛋白 2 水平及其对重度子痫前期患者胎儿多普勒超声的影响。
这是一项单中心病例对照研究，在范大学医院的妇产科进行。共有 90 名年龄在 18-40 岁的孕妇纳入研究。其中，30 名正常，30 名轻度子痫前期，30 名重度子痫前期。在本研究中，特别是在重度子痫前期患者中，研究了血清线粒体融合蛋白 2 水平以及重要的胎儿多普勒血流，如子宫动脉压、脐动脉压、第 1 分钟和第 5 分钟的 Apgar 评分、出生体重以及产后结局，如出生周数和新生儿重症监护病房患者数量之间的关系。
三组间线粒体融合蛋白 2 水平存在显著差异，其中重度子痫前期组最高（p<0.05）。母体血清线粒体融合蛋白 2 水平与子宫动脉压（r=0.543，p=0.007）、脐动脉压（r=0.238，p=0.008）、舒张压和收缩压呈正相关（p<0.001）。线粒体融合蛋白 2 预测子痫前期的受试者工作特征曲线如下：最佳截断值 1.6ng/mL；曲线下面积：0.861；95%CI：0.786-0.917；敏感性：83.9%；特异性：70.0%，（p≤0.001）。线粒体融合蛋白 2 增加一个单位，子痫前期的风险增加 4.21 倍，具有统计学意义。
本研究建议将线粒体融合蛋白 2 与胎儿多普勒超声结果结合使用，作为子痫前期严重程度的可靠指标。
