Albin Bayne, Adhikari Prashant, Tiwari Arjun Prasad, Qubbaj Khayzaran, Yang In Hong
Center for Biomedical Engineering and Science, Department of Mechanical Engineering and Engineering Science, University of North Carolina at Charlotte, Charlotte, NC 28223, USA.
iScience. 2024 Jan 30;27(3):109052. doi: 10.1016/j.isci.2024.109052. eCollection 2024 Mar 15.
Electrical stimulation (ESTIM) has shown to be an effective symptomatic treatment to treat pain associated with peripheral nerve damage. However, the neuroprotective mechanism of ESTIM on peripheral neuropathies is still unknown. In this study, we identified that ESTIM has the ability to enhance mitochondrial trafficking as a neuroprotective mechanism against chemotherapy-induced peripheral neuropathies (CIPNs). CIPN is a debilitating and painful sequalae of anti-cancer chemotherapy treatment which results in degeneration of peripheral nerves. Mitochondrial dynamics were analyzed within axons in response to two different antineoplastic mechanisms by chemotherapy drug treatments paclitaxel and oxaliplatin . Mitochondrial trafficking response to chemotherapy drug treatment was observed to decrease in conjunction with degeneration of distal axons. Using low-frequency ESTIM, we observed enhanced mitochondrial trafficking to be a neuroprotective mechanism against CIPN. This study confirms ESTIM enhances regeneration of peripheral nerves by increased mitochondrial trafficking.
电刺激（ESTIM）已被证明是治疗与周围神经损伤相关疼痛的一种有效对症治疗方法。然而，ESTIM对周围神经病变的神经保护机制仍不清楚。在本研究中，我们确定ESTIM具有增强线粒体运输的能力，作为一种针对化疗诱导的周围神经病变（CIPN）的神经保护机制。CIPN是抗癌化疗治疗中使人衰弱且疼痛的后遗症，会导致周围神经退化。通过化疗药物紫杉醇和奥沙利铂的两种不同抗肿瘤机制，分析轴突内的线粒体动力学。观察到线粒体运输对化疗药物治疗的反应随着远端轴突的退化而降低。使用低频ESTIM，我们观察到增强的线粒体运输是针对CIPN的一种神经保护机制。本研究证实ESTIM通过增加线粒体运输来增强周围神经的再生。
