Xu Kequan, Xia Peng, Chen Xi, Ma Weijie, Yuan Yufeng
Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China; Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Hubei, PR China.
Department of Hepatobiliary & Pancreatic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, 430071, PR China; Clinical Medicine Research Center for Minimally Invasive Procedure of Hepatobiliary & Pancreatic Diseases of Hubei Province, Hubei, PR China.
Trends Endocrinol Metab. 2023 May;34(5):278-291. doi: 10.1016/j.tem.2023.02.007. Epub 2023 Mar 6.
The challenges of hepatocellular carcinoma (HCC) pathogenesis, diagnosis, treatment, and prognosis evaluation are obvious. Hepatocyte-specific fatty acid (FA) metabolic reprogramming is an important marker of liver carcinogenesis and progression; elucidating its mechanism will help unravel the complexity of HCC pathogenesis. Noncoding RNAs (ncRNAs) play important roles in HCC development. Moreover, ncRNAs are important mediators of FA metabolism and are directly involved in the reprogramming of FA metabolism in HCC cells. Here we review significant new advances in understanding the mechanisms regulating HCC metabolism by focusing on ncRNA-mediated post-translational modifications of metabolic enzymes, metabolism-related transcription factors, and other proteins in associated signaling pathways. We also discuss the great therapeutic potential of targeting ncRNA-mediated FA metabolism reprogramming in HCC.
肝细胞癌（HCC）在发病机制、诊断、治疗及预后评估方面面临的挑战显而易见。肝细胞特异性脂肪酸（FA）代谢重编程是肝癌发生和进展的重要标志；阐明其机制将有助于揭示HCC发病机制的复杂性。非编码RNA（ncRNAs）在HCC发展过程中发挥着重要作用。此外，ncRNAs是FA代谢的重要调节因子，直接参与HCC细胞中FA代谢的重编程。在此，我们通过聚焦ncRNA介导的代谢酶、代谢相关转录因子及相关信号通路中其他蛋白质的翻译后修饰，综述在理解HCC代谢调控机制方面取得的重大新进展。我们还讨论了针对ncRNA介导的HCC中FA代谢重编程的巨大治疗潜力。
