Macedo Bruna Gois, Masuda Mia Y, Borges da Silva Henrique
Department of Immunology, Mayo Clinic, Scottsdale, AZ, United States.
Front Immunol. 2024 Feb 5;15:1355910. doi: 10.3389/fimmu.2024.1355910. eCollection 2024.
Tissue-resident memory T cells (T cells) are vital for the promotion of barrier immunity. The lung, a tissue constantly exposed to foreign pathogenic or non-pathogenic antigens, is not devoid of these cells. Lung T cells have been considered major players in either the protection against respiratory viral infections or the pathogenesis of lung allergies. Establishment of lung T cells rely on intrinsic and extrinsic factors. Among the extrinsic regulators of lung T cells, the magnitude of the impact of factors such as the route of antigen entry or the antigen natural tropism for the lung is not entirely clear. In this perspective, we provide a summary of the literature covering this subject and present some preliminary results on this potential dichotomy between antigen location versus antigen type. Finally, we propose a hypothesis to synthesize the potential contributions of these two variables for lung T cell development.
组织驻留记忆T细胞（T细胞）对于促进屏障免疫至关重要。肺是一个不断暴露于外来致病或非致病抗原的组织，其中也存在这些细胞。肺T细胞一直被认为是预防呼吸道病毒感染或引发肺部过敏的主要参与者。肺T细胞的形成依赖于内在和外在因素。在肺T细胞的外在调节因子中，诸如抗原进入途径或抗原对肺的天然嗜性等因素的影响程度尚不完全清楚。从这个角度来看，我们总结了涵盖该主题的文献，并展示了关于抗原位置与抗原类型之间这种潜在二分法的一些初步结果。最后，我们提出一个假设，以综合这两个变量对肺T细胞发育的潜在贡献。
