Department of Neurology, Sichuan Provincial People's Hospital, Chengdu, 610072, China.
University of Electronic Science & Technology of China, Chengdu, 610054, China.
Biomark Med. 2024 Feb;18(4):137-143. doi: 10.2217/bmm-2023-0585. Epub 2024 Feb 20.
To explore the association between the neutrophil-to-platelet ratio (NPR) and futile recanalization (FR) in patients with acute ischemic stroke due to large vascular occlusions after endovascular therapy (EVT). FR after EVT was defined as a poor 90-day prognosis (modified Rankin scale [mRS] score ≥3) despite successful reperfusion (modified thrombolysis in cerebral infarction grade 2b-3). Patients were divided into high NPR (>35; n = 115) and low NPR (≤35; n = 81) groups. The FR rate was significantly higher in the high NPR group than low NPR group (81.74 vs 55.56%; p = 0.000). NPR was independently associated with FR (odds ratio: 2.107; 95% CI: 1.017-4.364; p = 0.045). High NPR was associated with the risk of FR in patients with acute ischemic stroke due to large vascular occlusions.
探讨经血管内治疗（EVT）后，由于大血管闭塞导致急性缺血性卒中患者中性粒细胞与血小板比值（NPR）与无效再通（FR）之间的关系。 FR 定义为尽管再灌注成功（改良脑梗死溶栓分级 2b-3），但 90 天预后不良（改良 Rankin 量表 [mRS]评分≥3）。 将患者分为高 NPR（>35；n=115）和低 NPR（≤35；n=81）组。 高 NPR 组的 FR 率明显高于低 NPR 组（81.74% vs 55.56%；p=0.000）。 NPR 与 FR 独立相关（优势比：2.107；95%可信区间：1.017-4.364；p=0.045）。 在大血管闭塞导致的急性缺血性卒中患者中，高 NPR 与 FR 风险相关。
