Pascale Marco Maria, Frongillo Francesco, Vasta Pierangelo, Massimiani Giuseppe, Nure Erida, Agnes Salvatore
General Surgery and Liver Transplantation Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome 00168, Italy.
Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome 00168, Italy.
World J Transplant. 2025 Jun 18;15(2):100157. doi: 10.5500/wjt.v15.i2.100157.
The use of biomarkers, such as the neutrophil-to-lymphocyte ratio (NLR) and the neutrophil-to-platelet ratio (NPR), has shown promise in evaluating early outcomes after medical, interventional, and surgical treatments. NLR has emerged as an indicator of systemic inflammation and physiological stress. NPR has emerged as a potential indicator of inflammation and thrombotic risk in the context of surgical and radiological procedures.
To analyze the correlation of NLR and NPR with the development of post-liver transplantation (LT) early complications after stratification for hepatocellular carcinoma diagnosis.
Consecutive patients undergone LT between January 2019 and December 2023 were enrolled. Data regarding the concentration of hemoglobin and the differential leukocyte count on postoperative days (POD) 0, 1, 3, and 5 were collected.
The dataset included 161 consecutive patients undergone LT. Clavien-Dindo IV-V complications had a good correlation with NLR POD 1 ( = 0.05), NLR POD 3 ( < 0.001), NLR POD 7 ( < 0.001), NPR POD 3 ( < 0.001). In addition, the NPR ratio on POD 3 correlated with the onset of 30-day hemorrhage ( = 0.009). Finally, 30-day mortality had a significant association with the NLR POD 1 ( = 0.03) and with NLR POD 7 ( = 0.004), while NPR had a significant correlation with 30-day mortality in NPR POD 7 ( = 0.004).
The analysis of NLR and NPR are strictly correlated with Clavien-Dindo IV-V complications and 30-day post-LT death.
使用生物标志物，如中性粒细胞与淋巴细胞比值（NLR）和中性粒细胞与血小板比值（NPR），在评估药物、介入和手术治疗后的早期结果方面显示出前景。NLR已成为全身炎症和生理应激的指标。NPR已成为手术和放射学程序中炎症和血栓形成风险的潜在指标。
分析肝细胞癌诊断分层后NLR和NPR与肝移植（LT）术后早期并发症发生的相关性。
纳入2019年1月至2023年12月期间连续接受LT的患者。收集术后第0、1、3和5天的血红蛋白浓度和白细胞分类计数数据。
数据集包括161例连续接受LT的患者。Clavien-Dindo IV-V级并发症与术后第1天的NLR（P = 0.05）、术后第3天的NLR（P < 0.001）、术后第7天的NLR（P < 0.001）、术后第3天的NPR（P < 0.001）具有良好的相关性。此外，术后第3天的NPR比值与30天出血的发生相关（P = 0.009）。最后，30天死亡率与术后第1天的NLR（P = 0.03）和术后第7天的NLR（P = 0.004）显著相关，而NPR与术后第7天的30天死亡率显著相关（P = 0.004）。
NLR和NPR分析与Clavien-Dindo IV-V级并发症和LT术后30天死亡密切相关。
