School of Bioengineering and Biosciences, Lovely Professional University, Phagwara, 144411, India.
Curr Rev Clin Exp Pharmacol. 2024;19(4):379-386. doi: 10.2174/0127724328273252240201071756.
is a commercial spore probiotic known to treat multiple diseases. An increased interest in exploring the nutraceutical and probiotic properties of various microorganisms has made researchers explore more about these bacteria. The current trends in the healthcare industry are majorly focused on devising new therapies to avoid drug and pathogen resistance in patients. Antimicrobial peptides have been considered a source of antibiotics for a long time. Still, getting new therapies into the market is a big challenge. Members of the genus Bacillus have been reported to have a broad spectrum of antimicrobial peptides. One of the least explored species under this genus is , concerning peptide drug therapy. The applications of in treating or preventing gut dysbiosis and respiratory infections have been largely supported in the past two decades. Yet research is lacking in explaining the pathways at molecular levels in targeting pathogens. In this mini-review, we are going to summarise the research that has been reported so far about peptide extraction from , their mode of action and advantages to mankind, and the challenges lying in the isolation of peptides.
是一种商业孢子益生菌，已知可治疗多种疾病。人们对探索各种微生物的营养和益生菌特性的兴趣日益浓厚，促使研究人员对这些细菌进行了更多的研究。目前，医疗保健行业的主要趋势是设计新的治疗方法，以避免患者产生药物和病原体耐药性。抗菌肽长期以来一直被认为是抗生素的来源。然而，将新疗法推向市场仍然是一个巨大的挑战。芽孢杆菌属的成员被报道具有广谱的抗菌肽。在该属中，研究最少的物种之一是 ，涉及肽药物治疗。在过去的二十年中， 在治疗或预防肠道菌群失调和呼吸道感染方面的应用得到了广泛的支持。然而，在解释针对病原体的分子水平的途径方面，研究还很缺乏。在这个小型综述中，我们将总结迄今为止关于从 中提取肽、它们的作用模式和对人类的益处以及分离肽所面临的挑战的研究。
