Department of Radiation Oncology, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India.
J Cancer Res Ther. 2023 Oct 1;19(7):2070-2071. doi: 10.4103/jcrt.jcrt_1919_21. Epub 2023 Apr 25.
Primary rhabdomyosarcoma (RMS) of breast is a very rare malignancy usually affecting adolescent girls with a poor prognosis and no definitive treatment established. Here, we report a case of a 17-year-old girl who presented to us operated for a right breast mass with histopathology suggestive of RMS. She had undergone wide local excision with nipple-areola complex along with axillary node dissection for positive nodes. Immunohistochemistry was done which showed tumor cells which were positive for desmin and myogenin and were negative for leukocyte common antigen, cluster of differentiation 34 (CD-34), and AE1/AE3 which confirmed the diagnosis of RMS. She was planned for adjuvant chemotherapy but refused taking treatment. Two months later, she presented with local site recurrence for which re-excision was done, and she was started on adjuvant chemotherapy with vincristine, Adriamycin, and cyclophosphamide regimen after metastatic workup. She then received radiation treatment following which she is at present under follow-up with no signs of disease until now.
原发性乳腺横纹肌肉瘤（RMS）是一种非常罕见的恶性肿瘤，通常发生在青少年女孩中，预后不良，且尚未确定明确的治疗方法。在这里，我们报告了一例 17 岁女孩的病例，她因右侧乳腺肿块就诊，组织病理学提示 RMS。她接受了广泛的局部切除，包括乳头乳晕复合体和腋窝淋巴结清扫，因为淋巴结阳性。免疫组织化学显示肿瘤细胞阳性表达肌间蛋白和肌球蛋白，而白细胞共同抗原、分化群 34（CD-34）和 AE1/AE3 阴性，这证实了 RMS 的诊断。她计划接受辅助化疗，但拒绝接受治疗。两个月后，她出现局部复发，再次接受手术切除，在进行转移灶检查后开始接受长春新碱、阿霉素和环磷酰胺方案的辅助化疗。随后她接受了放疗，目前正在随访中，至今没有疾病迹象。
