Collares E F, Rossi M A, Macedo A da S
Arq Gastroenterol. 1985 Oct-Dec;22(4):192-5.
Fifty female Wistar weanling rats were fed a laboratory diet containing lactose (25 g/100 g of the final mixture) during 28 days. Following this period the lactose was substituted isocalorically by saccharose (25 g/100 g of the final mixture) and the diet given to the animals for 21 days. Thirty control rats of the same sex and weight received a laboratory diet containing saccharose (25 g/100 g of diet) during 49 days. The animals were weighed weekly. Subgroups of experimental and control rats were sacrificed at days 28, 30, 32, 35, 42 and 49. Rats given a diet containing lactose showed restriction of body weight gain. Upon rehabilitation the body weight of these animals increased rapidly. The external volume of the cecum and colon showed a significant increase during the 28-day period. After nutritional rehabilitation this change reduced gradually, beginning in the first week. Although the weight of the cecum reduced gradually during the rehabilitation period, the values were slightly augmented at day 49 as compared to controls. In conclusion, in the conditions of the present study, the consequences on the cecum and colon of adding lactose to the diet of rats are not persistent.
五十只雌性Wistar断奶大鼠在28天内喂食含有乳糖（25克/100克最终混合物）的实验室饮食。在此期间之后，乳糖被等热量地替换为蔗糖（25克/100克最终混合物），并将该饮食给予动物21天。三十只相同性别和体重的对照大鼠在49天内接受含有蔗糖（25克/100克饮食）的实验室饮食。每周对动物称重。在第28、30、32、35、42和49天处死实验大鼠和对照大鼠的亚组。给予含乳糖饮食的大鼠体重增加受限。康复后这些动物的体重迅速增加。盲肠和结肠的外部体积在28天期间显著增加。营养康复后，这种变化从第一周开始逐渐减少。尽管在康复期间盲肠重量逐渐减轻，但与对照组相比，在第49天数值略有增加。总之，在本研究条件下，给大鼠饮食中添加乳糖对盲肠和结肠的影响并非持久。
