Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
School of Public Health, North China University of Science and Technology, Hebei, Beijing, China.
Eur J Ophthalmol. 2024 Sep;34(5):1355-1364. doi: 10.1177/11206721241229317. Epub 2024 Feb 20.
To estimate the effect of atropine eyedrops at different concentrations for myopia control in children.
We conducted a Bayesian random-effects network meta-analysis based on randomized controlled trials (RCT). Primary outcomes include changes in spherical equivalent error (SER) and changes in axial length (AL), mean difference (MD) together with 95% credible interval (CrI) were used to evaluate the efficacy.
28 RCTs (6608 children) were included in this review. Comparing ten atropine eyedrops (0.0025%, 0.005%, 0.01%, 0.02%, 0.025%, 0.05%, 0.1%, 0.25%, 0.5% and 1% concentrations) with the placebo, the MDs and 95%CrIs of changes in SER are -0.006 (-0.269, 0.256) D, 0.216 (-0.078, 0.508) D, 0.146 (0.094, 0.199) D, 0.167 (0.039, 0.297) D, 0.201 (0.064, 0.341) D, 0.344 (0.251, 0.440) D, 0.255 (0.114, 0.396) D, 0.296 (0.140, 0.452) D, 0.331 (0.215, 0.447) D, and 0.286 (0.195, 0.337) D, respectively. The MDs and 95%CrIs of changes in AL are -0.048 (-0.182, 0.085) mm, -0.078 (-0.222, 0.066) mm, -0.095 (-0.130, -0.060) mm, -0.096 (-0.183, -0.009) mm, -0.083 (-0.164, -0.004) mm, -0.114 (-0.176, -0.056) mm, -0.134 (-0.198, -0.032) mm, -0.174 (-0.315, -0.061) mm, -0.184 (-0.291, -0.073) mm, and -0.171 (-0.203, -0.097) mm, respectively.Whether evaluated by SER or AL, 1% concentration ranks first in efficacy, but the risk of photophobia is 17 times higher than 0.01% concentration.
0.01% or higher concentration atropine eyedrops are effective for myopia control, while 0.0025% and 0.005% concentrations may not. As the concentration increases, the effect tends to increase, 1% concentration may have the strongest effect.
评估不同浓度阿托品滴眼液对儿童近视控制的效果。
我们基于随机对照试验（RCT）进行了贝叶斯随机效应网络荟萃分析。主要结局包括球镜等效误差（SER）变化和眼轴长度（AL）变化，使用均值差（MD）及其 95%可信区间（CrI）来评估疗效。
本综述纳入了 28 项 RCT（6608 名儿童）。与安慰剂相比，10 种阿托品滴眼液（0.0025%、0.005%、0.01%、0.02%、0.025%、0.05%、0.1%、0.25%、0.5%和 1%浓度）的 MD 和 95%CrI 中，SER 变化的 MD 分别为-0.006（-0.269，0.256）D、0.216（-0.078，0.508）D、0.146（0.094，0.199）D、0.167（0.039，0.297）D、0.201（0.064，0.341）D、0.344（0.251，0.440）D、0.255（0.114，0.396）D、0.296（0.140，0.452）D、0.331（0.215，0.447）D 和 0.286（0.195，0.337）D，AL 变化的 MD 和 95%CrI 分别为-0.048（-0.182，0.085）mm、-0.078（-0.222，0.066）mm、-0.095（-0.130，-0.060）mm、-0.096（-0.183，-0.009）mm、-0.083（-0.164，-0.004）mm、-0.114（-0.176，-0.056）mm、-0.134（-0.198，-0.032）mm、-0.174（-0.315，-0.061）mm、-0.184（-0.291，-0.073）mm 和-0.171（-0.203，-0.097）mm。无论是通过 SER 还是 AL 评估，1%浓度的疗效排名第一，但畏光风险是 0.01%浓度的 17 倍。
0.01%或更高浓度的阿托品滴眼液对近视控制有效，而 0.0025%和 0.005%浓度可能无效。随着浓度的增加，效果趋于增强，1%浓度的效果可能最强。
Zotero 插件