Zhu Qiu-Jian, Chen Xiao-Qing, Yan Shi-Chuan, Ma Gen-Fang, Niu Lan-Jun
Department of Ophthalmology, Lixiang Eye Hospital of Soochow University, Suzhou, China.
BMC Ophthalmol. 2025 Feb 17;25(1):77. doi: 10.1186/s12886-025-03910-6.
High anisometropia is often accompanied by amblyopia. One percent atropine penalization is an important treatment for anisometropic amblyopia and is as effective as occlusion therapy. On the other hand, 1% atropine had the strongest effect on controlling refractive error and axial length (AL) changes in myopic patients.
A female child was diagnosed with anisometropia at the age of two. Cycloplegic retinoscopy examination revealed refraction of + 2.5 diopters the right eye and -8.5/-1.5 × 120 diopters the left eye, and full correction spectacles and patching therapy were prescribed for the child. Anisometropic amblyopia was then diagnosed because the best corrected vision acuity in highly myopic eyes is 20/100. Owing to poor compliance, visual acuity recovery in the amblyopic eye was unsatisfactory, and 1% atropine was applied two times per week for the fellow (right) eye. Since then, the fellow eye has experienced rapid myopization, with the refractive error increasing to -7.5/-1.25 × 15 diopterswithin five years. In addition, the visual acuity of the amblyopic (left) eye has improved gradually to 20/20, although the refraction status has remained stable.
In this report, a high anisometropic amblyopia patient underwent rapid myopization in the fellow eye with constant use of 1% atropine, in contrast to the stable refraction status of the amblyopic eye.
高度屈光参差常伴有弱视。1%阿托品压抑疗法是治疗屈光参差性弱视的重要方法，其效果与遮盖疗法相当。另一方面，1%阿托品对控制近视患者的屈光不正和眼轴长度（AL）变化的作用最强。
一名女童两岁时被诊断为屈光参差。睫状肌麻痹验光检查显示右眼屈光度为+2.5，左眼为-8.5/-1.5×120，遂为该患儿开具了全矫眼镜及遮盖疗法。由于高度近视眼的最佳矫正视力为20/100，故诊断为屈光参差性弱视。因依从性差，弱视眼视力恢复不理想，遂对健侧（右）眼每周应用两次1%阿托品。此后，健侧眼迅速近视化，五年内屈光不正增加至-7.5/-1.25×15。此外，弱视（左）眼视力逐渐提高至20/20，但其屈光状态保持稳定。
在本报告中，一名高度屈光参差性弱视患者在持续使用1%阿托品的情况下，健侧眼出现迅速近视化，而弱视眼的屈光状态保持稳定。
