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胎儿肺间质肿瘤：一项侧重于下一代测序的综合病例研究

Fetal Lung Interstitial Tumor: A Comprehensive Case Study with an Emphasis on Next-Generation Sequencing.

作者信息

Jung Yoo Jin, Jung Seongyeon, Koh Jiwon, Koh Jaemoon, Jeon Yoon Kyung, Park Sung-Hye, Kim Eun Na, Kang Chang Hyun

机构信息

Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

Department of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.

出版信息

J Chest Surg. 2024 Jul 5;57(4):408-412. doi: 10.5090/jcs.23.154. Epub 2024 Feb 21.

DOI:10.5090/jcs.23.154
PMID:38378637
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11240089/
Abstract

Fetal lung interstitial tumor (FLIT), which is characterized by immature interstitial cells resembling the fetal lung parenchyma of 20 to 24 weeks of gestation, is a rare respiratory neoplasm. This study presents the first reported FLIT in Korea. It also aims to refine the diagnostic method of FLIT and increase the accuracy of prognostic assessment by using next-generation sequencing to check for anaplastic lymphoma receptor tyrosine kinase (anaplastic lymphoma kinase) gene rearrangement. Although the initial prognosis for FLIT has been promising since its first report in 2010, certain pathological features are associated with poorer outcomes. Therefore, achieving an accurate diagnosis of FLIT is crucial for avoiding unnecessary treatments beyond surgical resection.

摘要

胎儿肺间质瘤（FLIT）是一种罕见的呼吸肿瘤，其特征是存在类似于妊娠20至24周胎儿肺实质的未成熟间质细胞。本研究报告了韩国首例FLIT病例。该研究还旨在完善FLIT的诊断方法，并通过使用下一代测序检查间变性淋巴瘤受体酪氨酸激酶（间变性淋巴瘤激酶）基因重排，提高预后评估的准确性。尽管自2010年首次报告以来，FLIT的初始预后一直很乐观，但某些病理特征与较差的预后相关。因此，准确诊断FLIT对于避免手术切除以外的不必要治疗至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fca/11240089/e78b3075b1b6/jcs-57-4-408-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fca/11240089/2034c6f6d41e/jcs-57-4-408-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fca/11240089/16fab0c7bb03/jcs-57-4-408-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fca/11240089/e78b3075b1b6/jcs-57-4-408-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fca/11240089/2034c6f6d41e/jcs-57-4-408-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fca/11240089/16fab0c7bb03/jcs-57-4-408-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6fca/11240089/e78b3075b1b6/jcs-57-4-408-f3.jpg

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本文引用的文献

1
Fetal Lung Interstitial Tumor (FLIT): Review of The Literature.胎儿肺间质瘤（FLIT）：文献综述
Children (Basel). 2023 May 2;10(5):828. doi: 10.3390/children10050828.
2
Fetal lung interstitial tumor: An uncommon pediatric pulmonary neoplasm.胎儿肺间质瘤：一种罕见的儿科肺部肿瘤。
Lung India. 2021 Mar-Apr;38(2):186-190. doi: 10.4103/lungindia.lungindia_646_20.
3
Fetal lung interstitial tumor: Prenatal presentation of a rare fetal malignancy.胎儿肺间质瘤：一种罕见胎儿恶性肿瘤的产前表现。
J Neonatal Perinatal Med. 2019;12(4):473-477. doi: 10.3233/NPM-180059.
4
Neonatal congenital lung tumors - the importance of mid-second-trimester ultrasound as a diagnostic clue.新生儿先天性肺肿瘤——孕中期超声作为诊断线索的重要性
Pediatr Radiol. 2017 Dec;47(13):1766-1775. doi: 10.1007/s00247-017-3953-3. Epub 2017 Sep 7.
5
Identification of novel ALK rearrangement A2M-ALK in a neonate with fetal lung interstitial tumor.在一名患有胎儿肺间质瘤的新生儿中鉴定出新型ALK重排A2M-ALK 。
Genes Chromosomes Cancer. 2014 Oct;53(10):865-74. doi: 10.1002/gcc.22199. Epub 2014 Jun 26.
6
Fetal lung interstitial tumor (FLIT): A proposed newly recognized lung tumor of infancy to be differentiated from cystic pleuropulmonary blastoma and other developmental pulmonary lesions.胎儿肺间质肿瘤（FLIT）：一种新认识的婴儿期肺部肿瘤，需要与囊状胸膜肺母细胞瘤和其他发育性肺病变相鉴别。
Am J Surg Pathol. 2010 Dec;34(12):1762-72. doi: 10.1097/PAS.0b013e3181faf212.