State Key Laboratory of Reproductive Medicine and Offspring Health, Clinical Center of Reproductive Medicine, The First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, China.
Reprod Sci. 2024 Jul;31(7):1936-1947. doi: 10.1007/s43032-024-01464-4. Epub 2024 Feb 20.
Dietary supplements are gaining recognition as potential influencers of female reproductive health, but their connection to endometriosis risk remains underexplored. This study addressed this gap, examining the impact of daily dietary supplement intake on the initiation and progression of endometriosis. To explore this, a cross-sectional study was conducted involving 3950 participants representative of the US population from the 1999-2006 National Health and Nutrition Examination Survey (NHANES). Infertility was determined by a question on year-long attempts to become pregnant. Unweighted and weighted multivariate logistic regression analyses assessed the association between dietary supplements and endometriosis risk. Subgroup analysis was conducted based on the participants' body mass index (BMI). The results revealed intriguing patterns. Specifically, higher dietary fiber content (Q4 vs Q1: OR = 0.56, 95% CI = (0.37,0.84), P = 0.0062) and density (Q4 vs Q1: OR = 0.55, 95% CI = (0.38,0.81), P = 0.0035) were linked to reduced risk of endometriosis. Protein content (Q4 vs Q1: OR = 0.47, 95% CI = (0.31,0.74), P = 0.0011) and density (Q4 vs Q1: OR = 0.63, 95% CI = (0.45,0.88), P = 0.0096) similarly exhibited a negative association with endometriosis risk. Interestingly, when stratified by BMI, these effects were pronounced in normal-weight women, whereas they were not evident in the overweight and obese subgroup. Protein content and density showed no significant associations across subpopulations. In conclusion, this study established a negative relationship between dietary fiber and endometriosis, particularly notable in normal-weight women. Future research is essential to validate these findings and establish a causal link between dietary fiber and endometriosis.
膳食补充剂作为女性生殖健康的潜在影响因素越来越受到关注，但它们与子宫内膜异位症风险的关系仍未得到充分探索。本研究旨在探讨这一空白，研究每日膳食补充剂摄入对子宫内膜异位症发生和进展的影响。为了探讨这一问题，我们进行了一项横断面研究，共纳入了 3950 名来自美国 1999-2006 年国家健康与营养调查（NHANES）的代表性人群。通过询问一年来尝试怀孕的情况来确定不孕。未加权和加权多变量逻辑回归分析评估了膳食补充剂与子宫内膜异位症风险之间的关联。根据参与者的体重指数（BMI）进行亚组分析。结果揭示了一些有趣的模式。具体来说，较高的膳食纤维含量（Q4 与 Q1：OR=0.56，95%CI=（0.37，0.84），P=0.0062）和密度（Q4 与 Q1：OR=0.55，95%CI=（0.38，0.81），P=0.0035）与子宫内膜异位症风险降低相关。蛋白质含量（Q4 与 Q1：OR=0.47，95%CI=（0.31，0.74），P=0.0011）和密度（Q4 与 Q1：OR=0.63，95%CI=（0.45，0.88），P=0.0096）也与子宫内膜异位症风险呈负相关。有趣的是，按 BMI 分层时，这些效应在正常体重女性中更为明显，而在超重和肥胖亚组中则不明显。蛋白质含量和密度在各亚组之间无显著关联。总之，本研究确立了膳食纤维与子宫内膜异位症之间的负相关关系，在正常体重女性中尤为明显。未来的研究对于验证这些发现并建立膳食纤维与子宫内膜异位症之间的因果关系至关重要。
