The Second People's Hospital of Jingdezhen, Jingdezhen, Jiangxi, China.
PLoS One. 2024 Jun 6;19(6):e0304591. doi: 10.1371/journal.pone.0304591. eCollection 2024.
The systemic immuno-inflammatory index (SII), a novel immune marker of inflammation, has not been previously associated with endometriosis. The objective of this research is to explore the link between SII and the occurrence of endometriosis.
Utilizing data from the National Health and Nutrition Examination Survey (NHANES) spanning 2001 to 2006, we screened and extracted relevant information from the population. Participants missing data on either SII or endometriosis were excluded. We divided the remaining cohort into quartiles based on SII levels: Q1 (SII < 249, n = 848), Q2 (249 ≤ SII < 604.55, n = 847), Q3 (604.55 ≤ SII < 825.35, n = 847), and Q4 (SII ≥ 852.35, n = 848). Multiple linear regression and smooth curve fitting techniques, were to evaluate the non-linear association between SII and endometriosis.
The study included 3,390 adults aged 20 to 55. Multiple linear regression analysis revealed a significant positive correlation between SII and endometriosis [3.14, 95% CI (2.22, 4.45), P < 0.01]. This correlation was consistent across subgroups defined by marital status, poverty income ratio, BMI, alcohol consumption, and age at first menstrual period. However, the relationship between SII and endometriosis was significantly modified by age, education, and history of pregnancy in the stratified analyses. The curve fitting indicated an S-shaped curve, with an inflection point at SII = 1105.76.
The SII may serve as a predictive marker for endometriosis risk among women in the United States, offering a potentially simple and cost-effective approach. However, given the cross-sectional design of this investigation, further validation in prospective studies is necessary.
系统性免疫炎症指数（SII）是一种新的炎症免疫标志物，先前尚未与子宫内膜异位症相关联。本研究旨在探讨 SII 与子宫内膜异位症发生之间的关系。
利用 2001 年至 2006 年期间国家健康和营养检查调查（NHANES）的数据，我们从人群中筛选并提取了相关信息。排除了 SII 或子宫内膜异位症数据缺失的参与者。我们根据 SII 水平将剩余队列分为四组：Q1（SII<249，n=848）、Q2（249≤SII<604.55，n=847）、Q3（604.55≤SII<825.35，n=847）和 Q4（SII≥852.35，n=848）。采用多元线性回归和光滑曲线拟合技术评估 SII 与子宫内膜异位症之间的非线性关系。
该研究共纳入 3390 名 20 至 55 岁的成年人。多元线性回归分析显示，SII 与子宫内膜异位症之间存在显著正相关[3.14，95%置信区间（2.22，4.45），P<0.01]。这种相关性在根据婚姻状况、贫困收入比、BMI、饮酒和初潮年龄定义的亚组中是一致的。然而，在分层分析中，SII 与子宫内膜异位症之间的关系受到年龄、教育和妊娠史的显著修饰。曲线拟合表明存在 S 形曲线，拐点在 SII=1105.76。
SII 可能成为美国女性子宫内膜异位症风险的预测标志物，提供了一种简单且具有成本效益的方法。然而，由于本研究为横断面设计，需要进一步在前瞻性研究中进行验证。
