Hauner H, Glatting G, Ditschuneit H H, Pfeiffer E F
Department of Internal Medicine I, Universität Ulm, FRG.
Exp Clin Endocrinol. 1988 Aug;91(3):350-4. doi: 10.1055/s-0029-1210768.
The effects of the opiates beta-endorphin, dynorphin, met-enkephalin, leu-enkephalin, morphine and of the opiate-antagonist naloxone on glucose metabolism and lipolysis were studied in isolated rat adipocytes. None of the tested substances was found to alter 125I-Insulin binding. The opiates did not influence 2-deoxy-glucose uptake or glucose incorporation into lipids. They also did not exhibit a lipolytic activity. We conclude that the disturbances of glucose homeostasis induced by endogenous opiates are not mediated by an effect on peripheral glucose metabolism.
在分离的大鼠脂肪细胞中研究了阿片类物质β-内啡肽、强啡肽、甲硫氨酸脑啡肽、亮氨酸脑啡肽、吗啡以及阿片类拮抗剂纳洛酮对葡萄糖代谢和脂肪分解的影响。未发现所测试的任何物质会改变125I-胰岛素结合。阿片类物质不影响2-脱氧葡萄糖摄取或葡萄糖掺入脂质。它们也未表现出脂肪分解活性。我们得出结论，内源性阿片类物质引起的葡萄糖稳态紊乱并非由对外周葡萄糖代谢的影响介导。
