Sastry K V, Subhadra K
Environ Res. 1985 Feb;36(1):32-45. doi: 10.1016/0013-9351(85)90005-2.
Alterations in the activities of some enzymes in a freshwater catfish, Heteropneustes fossilis, have been examined in liver, kidney, intestine, ovary, gills, and muscles after exposure to 0.26 mg/liter of cadmium for 15, 30, and 60 days. The fish were hyperglycemic and hyperlactemic after 15 and 30 days of exposure. The liver and muscle glycogen content was depleted in the first two periods of exposure. In contrast, 60 days of cadmium treatment increased the glycogen content of the two tissues. Liver lactic acid level was elevated after 15 days. Muscle lactic acid content fell significantly after 15 and 60 days of exposure, but it was elevated after 30 days. Acid phosphatase activity was inhibited in liver, ovary, and gills but the enzyme activity increased in kidney and intestine. The activity of alkaline phosphatase decreased in liver, kidney, and intestine but elevation was recorded in ovary and muscles. In all three exposure periods, hexokinase activity of kidney and ovary was inhibited but the enzyme activity increased in intestine. Hexokinase showed elevation in liver, gills, and muscle after 15 and 30 days of exposure and inhibition after 60 days of exposure. The activity of xanthine oxidase decreased in liver and muscles and elevated in the rest of the tissues. Glutamate dehydrogenase fell significantly in intestine, ovary, and gills. In liver, kidney, and muscles the enzyme activity was elevated. Liver, intestine, gills, and muscles showed elevation in aminoacid oxidase activity. However, the enzyme activity was inhibited in kidney and in ovary.
在暴露于0.26毫克/升镉15天、30天和60天后，对淡水鲶鱼（印度胡鲶）的肝脏、肾脏、肠道、卵巢、鳃和肌肉中某些酶的活性变化进行了研究。暴露15天和30天后，鱼出现高血糖和高乳酸血症。在前两个暴露阶段，肝脏和肌肉糖原含量减少。相比之下，镉处理60天后，这两个组织的糖原含量增加。暴露15天后，肝脏乳酸水平升高。暴露15天和60天后，肌肉乳酸含量显著下降，但在30天后升高。酸性磷酸酶活性在肝脏、卵巢和鳃中受到抑制，但在肾脏和肠道中酶活性增加。碱性磷酸酶活性在肝脏、肾脏和肠道中降低，但在卵巢和肌肉中升高。在所有三个暴露阶段，肾脏和卵巢的己糖激酶活性受到抑制，但在肠道中酶活性增加。暴露15天和30天后，肝脏、鳃和肌肉中的己糖激酶升高，暴露60天后受到抑制。黄嘌呤氧化酶活性在肝脏和肌肉中降低，在其他组织中升高。谷氨酸脱氢酶在肠道、卵巢和鳃中显著下降。在肝脏、肾脏和肌肉中，酶活性升高。肝脏、肠道、鳃和肌肉中的氨基酸氧化酶活性升高。然而，该酶活性在肾脏和卵巢中受到抑制。
