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加速 theta 爆发刺激:安全性、疗效和未来进展。

Accelerated Theta Burst Stimulation: Safety, Efficacy, and Future Advancements.

机构信息

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California.

Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California; Department of Psychiatry and Behavioral Sciences, Dell School of Medicine, Austin, Texas.

出版信息

Biol Psychiatry. 2024 Mar 15;95(6):523-535. doi: 10.1016/j.biopsych.2023.12.004.


DOI:10.1016/j.biopsych.2023.12.004
PMID:38383091
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10952126/
Abstract

Theta burst stimulation (TBS) is a noninvasive brain stimulation technique that can be used to modulate neural networks underlying psychiatric and neurological disorders. TBS can be delivered intermittently or continuously. The conventional intermittent TBS protocol is approved by the U.S. Food and Drug Administration to treat otherwise treatment-resistant depression, but the 6-week duration limits the applicability of this therapy. Accelerated TBS protocols present an opportunity to deliver higher pulse doses in shorter periods of time, thus resulting in faster and potentially more clinically effective treatment. However, the acceleration of TBS delivery raises questions regarding the relative safety, efficacy, and durability compared with conventional TBS protocols. In this review paper, we present the data from accelerated TBS trials to date that support the safety and effectiveness of accelerated protocols while acknowledging the need for more durability data. We discuss the stimulation parameters that seem to be important for the efficacy of accelerated TBS protocols and possible avenues for further optimization.

摘要

θ 爆发刺激(TBS)是一种非侵入性的脑刺激技术,可用于调节精神和神经障碍的神经网络。TBS 可以间歇性或连续性地传递。传统的间歇性 TBS 方案已获得美国食品和药物管理局批准,用于治疗其他治疗方法无效的抑郁症,但 6 周的持续时间限制了这种疗法的适用性。加速 TBS 方案提供了在更短的时间内给予更高脉冲剂量的机会,从而实现更快且可能更具临床疗效的治疗。然而,TBS 传递的加速引发了与传统 TBS 方案相比,关于相对安全性、疗效和持久性的问题。在这篇综述文章中,我们展示了迄今为止加速 TBS 试验的数据,这些数据支持加速方案的安全性和有效性,同时承认需要更多的持久性数据。我们讨论了似乎对加速 TBS 方案疗效很重要的刺激参数以及进一步优化的可能途径。

相似文献

[1]
Accelerated Theta Burst Stimulation: Safety, Efficacy, and Future Advancements.

Biol Psychiatry. 2024-3-15

[2]
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[3]
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[4]
Lack of early reduction in depression severity predicts treatment non-response with 10 Hz and accelerated theta burst repetitive transcranial magnetic stimulation in treatment-resistant depression.

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[5]
Theta burst stimulation for enhancing upper extremity motor functions after stroke: a systematic review of clinical and mechanistic evidence.

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[6]
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[7]
Accelerated Intermittent Theta-Burst Stimulation and Treatment-Refractory Bipolar Depression: A Randomized Clinical Trial.

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[8]
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[9]
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[10]
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引用本文的文献

[1]
Efficacy of 5x5 accelerated versus conventional repetitive transcranial magnetic stimulation (rTMS) for treatment-resistant depression.

Res Sq. 2025-8-19

[2]
Advances in theta-burst transcranial magnetic stimulation for auditory comprehension deficits in post-stroke aphasia.

Front Neurol. 2025-7-29

[3]
Effects of intermittent theta burst to the left dorsolateral prefrontal cortex on brain volumes and neurometabolites in people with alcohol use disorder: a preliminary investigation.

Front Hum Neurosci. 2025-7-22

[4]
Cerebellum Involvement in Visuo-vestibular Interaction for the Perception of Gravitational Direction: A Repetitive Transcranial Magnetic Stimulation Study.

eNeuro. 2025-7-30

[5]
A Customized Neural Transcranial Magnetic Stimulation Target for Functional Disability Among Veterans With Co-Occurring Alcohol Use Disorder and Mild Traumatic Brain Injury: Protocol for a Pilot Randomized Controlled Trial.

JMIR Res Protoc. 2025-6-23

[6]
Effects of noninvasive brain stimulation on motor functions in animal models of ischemia and trauma in the central nervous system.

Neural Regen Res. 2026-4-1

[7]
Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception.

Neurosci Bull. 2025-6-19

[8]
Lactobacillus johnsonii HL79 mitigate plateau environment-induced hippocampal dysfunction in mice.

AMB Express. 2025-6-19

[9]
Global trends and research hotspots in the treatment of mental disorders with transcranial magnetic stimulation: a bibliometric analysis.

Front Psychiatry. 2025-6-4

[10]
Continuous theta burst stimulation in the treatment of epilepsia partialis continua: a case series.

Bioelectron Med. 2025-5-23

本文引用的文献

[1]
Accelerated TMS - moving quickly into the future of depression treatment.

Neuropsychopharmacology. 2024-1

[2]
Repetitive Transcranial Magnetic Stimulation for Treatment-Resistant Depression: Mismatch of Evidence and Insurance Coverage Policies in the United States.

J Clin Psychiatry. 2023-4-26

[3]
Deep TMS H1 Coil treatment for depression: Results from a large post marketing data analysis.

Psychiatry Res. 2023-6

[4]
A Systematic Review Assessing Patient-Related Predictors of Response to Transcranial Magnetic Stimulation in Major Depressive Disorder.

Neuropsychiatr Dis Treat. 2023-3-8

[5]
Functional Connectivity Mapping for rTMS Target Selection in Depression.

Am J Psychiatry. 2023-3-1

[6]
Effects of bilateral sequential theta-burst stimulation on functional connectivity in treatment-resistant depression: First results.

J Affect Disord. 2023-3-1

[7]
Effectiveness of accelerated intermittent theta burst stimulation for social cognition and negative symptoms among individuals with schizophrenia: A randomized controlled trial.

Psychiatry Res. 2023-2

[8]
Efficacy of Adjunctive D-Cycloserine to Intermittent Theta-Burst Stimulation for Major Depressive Disorder: A Randomized Clinical Trial.

JAMA Psychiatry. 2022-12-1

[9]
Adjunctive neuronavigated accelerated continuous theta-burst stimulation in obsessive-compulsive disorder: a randomized sham-controlled study.

CNS Spectr. 2023-8

[10]
Neuronavigation maximizes accuracy and precision in TMS positioning: Evidence from 11,230 distance, angle, and electric field modeling measurements.

Brain Stimul. 2022

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