Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California.
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California; Department of Psychiatry and Behavioral Sciences, Dell School of Medicine, Austin, Texas.
Biol Psychiatry. 2024 Mar 15;95(6):523-535. doi: 10.1016/j.biopsych.2023.12.004.
Theta burst stimulation (TBS) is a noninvasive brain stimulation technique that can be used to modulate neural networks underlying psychiatric and neurological disorders. TBS can be delivered intermittently or continuously. The conventional intermittent TBS protocol is approved by the U.S. Food and Drug Administration to treat otherwise treatment-resistant depression, but the 6-week duration limits the applicability of this therapy. Accelerated TBS protocols present an opportunity to deliver higher pulse doses in shorter periods of time, thus resulting in faster and potentially more clinically effective treatment. However, the acceleration of TBS delivery raises questions regarding the relative safety, efficacy, and durability compared with conventional TBS protocols. In this review paper, we present the data from accelerated TBS trials to date that support the safety and effectiveness of accelerated protocols while acknowledging the need for more durability data. We discuss the stimulation parameters that seem to be important for the efficacy of accelerated TBS protocols and possible avenues for further optimization.
θ 爆发刺激(TBS)是一种非侵入性的脑刺激技术,可用于调节精神和神经障碍的神经网络。TBS 可以间歇性或连续性地传递。传统的间歇性 TBS 方案已获得美国食品和药物管理局批准,用于治疗其他治疗方法无效的抑郁症,但 6 周的持续时间限制了这种疗法的适用性。加速 TBS 方案提供了在更短的时间内给予更高脉冲剂量的机会,从而实现更快且可能更具临床疗效的治疗。然而,TBS 传递的加速引发了与传统 TBS 方案相比,关于相对安全性、疗效和持久性的问题。在这篇综述文章中,我们展示了迄今为止加速 TBS 试验的数据,这些数据支持加速方案的安全性和有效性,同时承认需要更多的持久性数据。我们讨论了似乎对加速 TBS 方案疗效很重要的刺激参数以及进一步优化的可能途径。
Biol Psychiatry. 2024-3-15
Eur J Med Res. 2024-11-29
J Clin Neurophysiol. 2011-2
Bioelectron Med. 2025-5-23
Neuropsychopharmacology. 2024-1
Neuropsychiatr Dis Treat. 2023-3-8
Am J Psychiatry. 2023-3-1