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在用非诱变化学试剂处理的HeLa细胞中紫外线照射的腺病毒2的增强再激活。

Enhanced reactivation of UV-irradiated adenovirus 2 in HeLa cells treated with non-mutagenic chemical agents.

作者信息

Piperakis S M, McLennan A G

出版信息

Mutat Res. 1985 Mar;142(3):83-5. doi: 10.1016/0165-7992(85)90044-2.

DOI:10.1016/0165-7992(85)90044-2
PMID:3838362
Abstract

Treatment of HeLa cells with ethanol and sodium arsenite, compounds which are known to elicit the heat-shock response, before infection with UV-irradiated adenovirus 2 has been found to result in the enhanced reactivation of the damaged virus in a manner similar to that obtained by pre-irradiation or heating of the cells. Enhanced reactivation may be the result of the inhibition of DNA synthesis caused by these agents since hydroxyurea also produced a significant enhancement.

摘要

在用紫外线照射的腺病毒2感染之前,用乙醇和亚砷酸钠(已知可引发热休克反应的化合物)处理海拉细胞,已发现会导致受损病毒的再激活增强,其方式类似于通过对细胞进行预照射或加热所获得的方式。增强的再激活可能是这些试剂引起的DNA合成抑制的结果,因为羟基脲也产生了显著的增强作用。

相似文献

1
Enhanced reactivation of UV-irradiated adenovirus 2 in HeLa cells treated with non-mutagenic chemical agents.在用非诱变化学试剂处理的HeLa细胞中紫外线照射的腺病毒2的增强再激活。
Mutat Res. 1985 Mar;142(3):83-5. doi: 10.1016/0165-7992(85)90044-2.
2
Heat-enhanced reactivation of UV-irradiated adenovirus 2 is not associated with enhanced mutagenesis in HeLa cells.热增强紫外线照射的腺病毒2的再激活与HeLa细胞中诱变增强无关。
Mutat Res. 1984 Apr;139(4):173-6. doi: 10.1016/0165-7992(84)90123-4.
3
Enhanced reactivation of UV-irradiated adenovirus 2 is not associated with enhanced mutagenesis in carcinogen-pretreated HeLa cells.紫外线照射的腺病毒2的增强再激活与致癌物预处理的HeLa细胞中的诱变增强无关。
Mutat Res. 1987 Nov;192(3):203-6. doi: 10.1016/0165-7992(87)90056-x.
4
Delayed expression of enhanced reactivation and decreased mutagenesis of UV-irradiated adenovirus in UV-irradiated ataxia telangiectasia fibroblasts.紫外线照射的共济失调毛细血管扩张症成纤维细胞中紫外线照射的腺病毒再激活增强和诱变减少的延迟表达
Mutagenesis. 1988 Sep;3(5):389-95. doi: 10.1093/mutage/3.5.389.
5
Possible role of localized protein denaturation in the mechanism of induction of thermotolerance by heat, sodium-arsenite and ethanol.局部蛋白质变性在热、亚砷酸钠和乙醇诱导耐热性机制中的可能作用。
Int J Hyperthermia. 1993 Jan-Feb;9(1):151-62. doi: 10.3109/02656739309061487.
6
Enhanced reactivation and mutagenesis of UV-irradiated adenovirus in normal human fibroblasts.紫外线照射的腺病毒在正常人成纤维细胞中的再激活和诱变增强
Mutagenesis. 1988 Mar;3(2):157-64. doi: 10.1093/mutage/3.2.157.
7
Effect of cycloheximide or puromycin on induction of thermotolerance by sodium arsenite in Chinese hamster ovary cells: involvement of heat shock proteins.环己酰亚胺或嘌呤霉素对亚砷酸钠诱导中国仓鼠卵巢细胞耐热性的影响:热休克蛋白的作用
J Cell Physiol. 1987 Jul;132(1):41-8. doi: 10.1002/jcp.1041320106.
8
The two inducible responses, SOS and heat-shock, in Escherichia coli act synergistically during Weigle reactivation of the bacteriophage phiX174.在噬菌体φX174的韦格勒再活化过程中,大肠杆菌中的两种诱导性反应,即SOS反应和热休克反应,协同发挥作用。
Int J Radiat Biol. 2007 Jul;83(7):463-9. doi: 10.1080/09553000701371389.
9
Gamma-ray-enhanced reactivation of UV-irradiated adenovirus in normal human fibroblasts.γ射线增强紫外线照射的腺病毒在正常人成纤维细胞中的再激活。
Mutat Res. 1979 Mar;60(1):33-41. doi: 10.1016/0027-5107(79)90207-0.
10
Hyperthermia and the heat-shock proteins of HeLa cells.HeLa细胞的热疗与热休克蛋白
Br J Cancer. 1982 Jun;45(6):953-63. doi: 10.1038/bjc.1982.148.

引用本文的文献

1
Heat-inducible reactivation of UV-damaged bacteriophage lambda.紫外线损伤的噬菌体λ的热诱导再活化
Mol Gen Genet. 1991 Apr;226(1-2):113-9. doi: 10.1007/BF00273594.