Flannelly K J, Lim H L, Diamond M, Blanchard D C, Blanchard R J
Pharmacol Biochem Behav. 1985 Jan;22(1):1-4. doi: 10.1016/0091-3057(85)90476-9.
The copulatory performance of 18 sexually experienced male rats was tested 30 min after IP injection of the phenylpiperazine, Fluprazine Hydrochloride (4 and 8 mg/kg), or saline solution. Three 20-min tests with an estrous female were conducted at weekly intervals. Each drug dose produced a significant depressive effect on copulatory behavior (latency to and frequency of intromissions and ejaculations) without affecting social investigation. The increased latencies to mounting and intromission observed at both doses suggest that the primary action of the Fluprazine Hydrochloride is to interfere with the transition from social to copulatory patterns. Although the drug's mode of action is currently unknown, the present findings suggest that it operates on some common mediator of sexual and aggressive behavior.
在腹腔注射苯基哌嗪、盐酸氟哌嗪（4毫克/千克和8毫克/千克）或生理盐水溶液30分钟后，对18只具有性经验的雄性大鼠的交配行为进行了测试。每隔一周对处于发情期的雌性大鼠进行三次20分钟的测试。每种药物剂量对交配行为（插入和射精的潜伏期及频率）均产生显著的抑制作用，而不影响社交探究行为。在两种剂量下观察到的爬上和插入潜伏期增加表明，盐酸氟哌嗪的主要作用是干扰从社交模式向交配模式的转变。尽管目前尚不清楚该药物的作用方式，但目前的研究结果表明，它作用于性和攻击行为的某种共同介质。
