Drajer S, Vazquez A, Cercós H, Torres H, Cohn J L, Romero N, Faerman G, Soifer S, Nijensohn C M
Am Heart J. 1985 Mar;109(3 Pt 2):712-5. doi: 10.1016/0002-8703(85)90689-1.
In this report we present the results of hemodynamic monitoring with a Swan-Ganz balloon catheter in 14 patients with heart failure associated with acute myocardial infarction, before and during 8 hours after a single oral dose of molsidomine (6 mg). Molsidomine induced the following changes: heart rate was reduced between 1.6% and 4.7% (significant at 4 hours, p less than 0.05); systolic blood pressure decreased 8.4% at 1 hour (p less than 0.05); pulmonary capillary pressure decreased approximately 30% (significant and lasting until 8 hours after administration, p less than 0.002); cardiac index did not change significantly, although individual analysis showed an increase in 6 of 12 cases; stroke volume index increased by 6% (significant at 1 hour, p less than 0.025); and left ventricular stroke work index increased from 9.8% to 24.5% (significant at 1 and 4 hours, p less than 0.01 and 0.025). These findings show the beneficial hemodynamic effects of molsidomine in patients with heart failure complicating acute myocardial infarction.
在本报告中，我们呈现了14例急性心肌梗死合并心力衰竭患者在单次口服一剂莫索尼定（6毫克）之前及之后8小时内，使用Swan-Ganz气囊导管进行血流动力学监测的结果。莫索尼定引起了以下变化：心率降低1.6%至4.7%（4小时时显著，p<0.05）；收缩压在1小时时下降8.4%（p<0.05）；肺毛细血管压下降约30%（显著且持续至给药后8小时，p<0.002）；心脏指数无显著变化，尽管个体分析显示12例中有6例升高；每搏量指数增加6%（1小时时显著，p<0.025）；左心室每搏功指数从9.8%增至24.5%（1小时和4小时时显著，p<0.01和0.025）。这些发现表明莫索尼定对急性心肌梗死合并心力衰竭患者具有有益的血流动力学效应。
