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ISG15 通过 ATG7 促进胰腺癌细胞的进展和吉西他滨耐药性。

ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7.

机构信息

Department of Radiation Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, China.

出版信息

Int J Biol Sci. 2024 Jan 21;20(4):1180-1193. doi: 10.7150/ijbs.85424. eCollection 2024.

DOI:10.7150/ijbs.85424
PMID:38385083
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10878160/
Abstract

Chemoresistance is an obstacle of improving pancreatic cancer (PC) prognosis. However, the biological function of ISG15 in PC and whether it correlates with the resistance to chemotherapy are still unknown. Here, we aimed to reveal the clinical significance of ISG15 in PC and its regulatory mechanism in cancer progression and resistance to therapy. The level of ISG15, a protein involved in post-translational modifications, is elevated in PC tissues. Clinically, higher ISG15 expression correlates with higher PC grades, stronger resistance to treatment and poorer prognosis. Moreover, ISG15 promotes the proliferation, migration, invasion, colony formation of PC cells and resistance to Gemcitabine, a classic chemotherapeutics for PC, both and . ISG15 promotes progression and resistance to therapy in PC cells by binding to ATG7, reducing its degradation, and thereby leading to enhanced autophagy in PC cells. ISG15 may be used as both a potential diagnosis marker and sensitizer for chemotherapeutics such as Gemcitabine during PC intervention.

摘要

化疗耐药性是改善胰腺癌 (PC) 预后的障碍。然而，ISG15 在 PC 中的生物学功能及其与化疗耐药性的相关性尚不清楚。在这里，我们旨在揭示 ISG15 在 PC 中的临床意义及其在癌症进展和治疗耐药性中的调节机制。涉及翻译后修饰的蛋白质 ISG15 的水平在 PC 组织中升高。临床上，较高的 ISG15 表达与较高的 PC 分级、更强的治疗抵抗性和更差的预后相关。此外，ISG15 促进 PC 细胞的增殖、迁移、侵袭、集落形成以及对吉西他滨（一种用于 PC 的经典化疗药物）的耐药性。ISG15 通过与 ATG7 结合，减少其降解，从而增强 PC 细胞中的自噬，从而促进 PC 细胞的进展和对治疗的耐药性。ISG15 可能在 PC 干预期间用作吉西他滨等化疗药物的潜在诊断标志物和增敏剂。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b37/10878160/03b43779552f/ijbsv20p1180g007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5b37/10878160/03b43779552f/ijbsv20p1180g007.jpg

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2
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Cell Death Differ. 2020 Aug;27(8):2517-2530. doi: 10.1038/s41418-020-0519-y. Epub 2020 Mar 3.
3
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5
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