State Key Laboratory of Basis and New Drug Development of Natural and Nuclear Drugs, Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
Comprehensive Utilization of Edible and Medicinal Plant Resources Engineering Technology Research Center, Zhengzhou Key Laboratory of Synthetic Biology of Natural Products, Zhengzhou Key Laboratory of Medicinal Resources Research, Huanghe Science and Technology College, Zhengzhou 450006, People's Republic of China.
J Agric Food Chem. 2024 Mar 6;72(9):4518-4537. doi: 10.1021/acs.jafc.3c06690. Epub 2024 Feb 22.
Asterric acid and its analogs belong to diphenyl ethers (DPEs) with multiple substitutions on A/B aromatic rings. This member of DPEs originates from the polyketide pathway and displays a wide range of biological effects. Though the structures of asterric acid analogs are not complex, there were only more than 50 asterric acid analogs found in nature from 1960 to 2023. In this review, the structures, bioactivities, and biosynthesis of asterric acid analogs are summarized. More importantly, the empirical rule about the shielding effect of B-ring on H-6 is suggested, and this provides a convenient and useful way to analyze the NMR spectral data of asterric acid analogs, based on which the chemical shift values of the A-ring in some asterric acid analogs are revised.
绵马酸及其类似物属于二苯醚（DPEs），在 A/B 芳环上具有多个取代基。该 DPEs 成员来源于聚酮途径，具有广泛的生物活性。尽管绵马酸类似物的结构并不复杂，但从 1960 年到 2023 年，仅在自然界中就发现了 50 多种绵马酸类似物。本文综述了绵马酸类似物的结构、生物活性和生物合成。更重要的是，提出了 B 环对 H-6 屏蔽效应的经验规律，为分析绵马酸类似物的 NMR 谱数据提供了一种方便、有用的方法，据此修正了一些绵马酸类似物中 A 环的化学位移值。
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