产前暴露于全氟和多氟烷基物质与儿童行为问题。
Prenatal exposure to per- and polyfluoroalkyl substances and child behavioral problems.
机构信息
Department of Environmental Science, Baylor University, Waco, TX, USA.
Department of Public Health Sciences, University of California, Davis, CA, USA.
出版信息
Environ Res. 2024 Jun 15;251(Pt 1):118511. doi: 10.1016/j.envres.2024.118511. Epub 2024 Feb 21.
BACKGROUND
Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely affect child behaviors; however, findings of epidemiologic studies are inconsistent. We examined prenatal PFAS exposure in association with child behavioral problems.
METHODS
Participants were 177 mother-child pairs from MARBLES (Markers of Autism Risk in Babies - Learning Early Signs), a cohort with elevated familial likelihood of autism spectrum disorder (ASD). We quantified nine PFAS in maternal serum (1-3 samples per mother) collected from the 1st to 3rd trimesters of pregnancy. Child behavioral problems were assessed at 3 years of age using the Child Behavior Checklist (CBCL), developed to test for various behavioral problems of children. We examined associations of the CBCL scores with individual PFAS concentrations and with their mixture using negative binomial regression and weighted quantile sum regression models.
RESULTS
Higher prenatal perfluorononanoate (PFNA) concentrations were associated with higher scores of externalizing problems [β = 0.16, 95% CI (0.01, 0.32)] and aggressive behavior [β = 0.17 (0.01, 0.32)]. Higher PFNA, perfluorooctane sulfonate (PFOS), and perfluorodecanoate (PFDA) were associated with higher scores of sleep problems [β = 0.34 (0.15, 0.54) for PFNA, β = 0.20 (0.02, 0.37) for PFOS, and β = 0.19 (0.00, 0.37) for PFDA]. No significant associations observed for typically developing children, whereas PFOS, PFNA, and PFDA were associated with several behavioral problems among children diagnosed with ASD or other neurodevelopmental concerns. Exposure to a mixture of PFAS was associated with higher scores of sleep problems and aggressive behavior, mostly contributed by PFNA and PFDA.
CONCLUSIONS
Our study showed that prenatal exposure to some PFAS could increase child behavioral problems at 3 years of age. However, our results should be interpreted with caution because we relied on data from a cohort with increased familial likelihood of ASD and thereby had more behavioral problems.
背景
围孕期接触全氟和多氟烷基物质（PFAS）可能对儿童行为产生不利影响，但流行病学研究的结果并不一致。我们研究了围孕期 PFAS 暴露与儿童行为问题的关系。
方法
参与者为来自 MARBLES（婴儿自闭症风险标志物-学习早期迹象）的 177 对母婴，该队列具有自闭症谱系障碍（ASD）的家族高发倾向。我们在妊娠 1 至 3 个月期间采集了母亲血清中的 9 种 PFAS（每位母亲采集 1-3 个样本），并使用儿童行为检查表（CBCL）评估了 3 岁儿童的行为问题，该检查表用于测试儿童的各种行为问题。我们使用负二项回归和加权分位数和回归模型，研究了个体 PFAS 浓度及其混合物与 CBCL 评分之间的关联。
结果
较高的产前全氟壬酸（PFNA）浓度与较高的外化问题评分相关[β=0.16，95%置信区间（0.01，0.32）]和攻击行为[β=0.17（0.01，0.32）]。较高的 PFNA、全氟辛烷磺酸（PFOS）和全氟癸酸（PFDA）与睡眠问题评分较高相关[PFNA 为 β=0.34（0.15，0.54），PFOS 为 β=0.20（0.02，0.37），PFDA 为 β=0.19（0.00，0.37）]。在未被诊断为 ASD 或其他神经发育问题的正常发育儿童中未观察到显著关联，而 PFOS、PFNA 和 PFDA 与 ASD 或其他神经发育问题儿童的几种行为问题相关。PFAS 混合物的暴露与睡眠问题和攻击行为评分较高有关，主要由 PFNA 和 PFDA 引起。
结论
我们的研究表明，围孕期接触某些 PFAS 可能会增加 3 岁儿童的行为问题。然而，由于我们依赖于具有 ASD 家族高发倾向的队列的数据，因此我们的结果应谨慎解释，该队列的行为问题更多。
Zotero 插件