Kruse-Jarres J D
J Clin Chem Clin Biochem. 1979 Jul;17(7):457-63.
16 years ago Kadish (1963) Trans. Amer. Soc. Artif. Org. 9, 363--367) published his first pioneering experiments with an extracorporal blood glucose regulating machine. These experiments were fundamental to the development of an artificial endocrine pancreas that replaces the natural regulator of the blood glucose. Enormous improvements have been done as far as analytical and computer technology and algorithms are concerned. Satisfactory but time-limited insulin therapy of problematic diabetics is feasable and benefical. However, in spite of a very great miniaturization of the analytical device, of the computer system, or of the insulin delivery pump, we are still far away from a durable, or at least long-term implantation of an artificial endocrine pancreas.
16年前，卡迪什（1963年，《美国人工器官学会会刊》第9卷，第363 - 367页）发表了他关于体外血糖调节机器的首次开创性实验。这些实验对于开发替代血糖天然调节者的人工内分泌胰腺至关重要。就分析技术、计算机技术和算法而言，已经取得了巨大的进步。对问题糖尿病患者进行令人满意但有时间限制的胰岛素治疗是可行且有益的。然而，尽管分析设备、计算机系统或胰岛素输送泵已经实现了非常大程度的小型化，但我们距离持久地，或者至少是长期植入人工内分泌胰腺仍有很大差距。
