Buysschaert M, Lambotte L, Lambert A E
Nouv Presse Med. 1979;8(32):2597-601.
Fluctuations in blood glucose levels which occur in the brittle diabetic explain the difficulty of blood glucose control by insulin therapy as used at the present time. The artificial endocrine pancreas is a bedside device capable of maintaining blood sugar value within a normal range by the administration of adequate amounts of insulin or glucose given at the optimal time. The glycemic control of 11 brittle diabetics is improved during the 5 days after a 24 hour connection with the AEP. A better determination of adequate subcutaneous doses of insulin, based on the circadian insulin profile infused by the artificial endocrine pancreas, achieved the improvement of glycemia. Glucagon profile preceeding, during and after AEP is also discussed. Using a method of two injections daily of a mixture acterapid and semi-lente, as a general rule it is found that approximately fifty per cent of the dose must be given in the acterapid form. Glucagon value decreases during the 24 h artificial endocrine pancreas. This is suggestive of a possible role of hyperglucagonemia in brittle diabetes.
脆性糖尿病患者血糖水平的波动解释了目前使用胰岛素治疗控制血糖的困难。人工内分泌胰腺是一种床边设备，能够通过在最佳时间给予适量的胰岛素或葡萄糖，将血糖值维持在正常范围内。11名脆性糖尿病患者在与人工内分泌胰腺连接24小时后的5天内，血糖控制得到改善。基于人工内分泌胰腺输注的昼夜胰岛素谱，更好地确定皮下胰岛素的适当剂量，实现了血糖的改善。还讨论了人工内分泌胰腺使用前、使用期间和使用后的胰高血糖素谱。使用每天两次注射速效胰岛素和半慢胰岛素混合物的方法，一般发现大约50%的剂量必须以速效胰岛素的形式给予。在24小时人工内分泌胰腺治疗期间，胰高血糖素值下降。这表明高胰高血糖素血症在脆性糖尿病中可能起作用。
