Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, China.
State Key Laboratory of Elemento-Organic Chemistry, Research Institute of Elemento-Organic Chemistry, College of Chemistry, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin 300071, China.
J Agric Food Chem. 2024 Mar 6;72(9):4658-4668. doi: 10.1021/acs.jafc.3c08161. Epub 2024 Feb 22.
Food security is an important issue in the 21st century; preventing and controlling crop diseases and pests are the key to solve this problem. The creation of new pesticides based on natural products is an important and effective method. Herein, coumarins were selected as parent structures, and a series of their derivatives were designed, synthesized, and evaluated for their antiviral activities, fungicidal activities, and insecticidal activities. We found that coumarin derivatives exhibited good to excellent antiviral activities against tobacco mosaic virus (TMV). The antiviral activities of , , , , , , and are better than that of ribavirin at 500 μg/mL. Molecular docking research showed that these compounds had a strong interaction with TMV CP. These compounds also showed broad-spectrum fungicidal activities against 14 plant pathogenic fungi. The EC values of , , , and are in the range of 1.56-8.65 μg/mL against , , , and . Most of the compounds also displayed good insecticidal activities against . Pesticide-likeness analysis showed that these compounds are following pesticide-likeness and have the potential to be developed as pesticide candidates. The present work lays a foundation for the discovery of novel pesticide lead compounds based on coumarin derivatives.
食品安全是 21 世纪的重要问题；预防和控制作物病虫害是解决这个问题的关键。基于天然产物开发新农药是一种重要且有效的方法。在此，我们选择香豆素作为母体结构，设计、合成了一系列香豆素衍生物，并对其抗病毒活性、杀菌活性和杀虫活性进行了评价。我们发现香豆素衍生物对烟草花叶病毒（TMV）表现出良好到优异的抗病毒活性。在 500μg/mL 时，,,,,, 和 的抗病毒活性优于利巴韦林。分子对接研究表明，这些化合物与 TMV CP 具有很强的相互作用。这些化合物还对 14 种植物病原菌表现出广谱杀菌活性。,, 和 的 EC 值在 1.56-8.65μg/mL 范围内。, 和 的 EC 值在 1.56-8.65μg/mL 范围内。大多数化合物对 也显示出良好的杀虫活性。农药相似性分析表明，这些化合物具有农药相似性，有潜力开发为农药候选物。本工作为基于香豆素衍生物发现新型农药先导化合物奠定了基础。
