Lv Min, Ding Haixia, Xu Hui
School of Marine Sciences, Ningbo University, Ningbo 315832, China.
College of Plant Protection, Northwest A&F University, Xianyang 712100, China.
Biology (Basel). 2025 May 22;14(6):588. doi: 10.3390/biology14060588.
Osthole is a natural coumarin-like compound isolated from the . In the last few years, this plant-derived product and its derivatives have aroused much attention for their interesting biological activities, including anticancer, anti-inflammatory, neuroprotective, and insecticidal effects. This review summarizes the recent progress on the biological activities of osthole and its derivatives from 2018 to early 2025, with a focus on their total synthesis, structural modifications, and mechanisms of action. Additionally, structure-activity relationships (SARs) of osthole derivatives are presented. This review aims to serve as a comprehensive reference for future research on osthole and its derivatives in both medicinal and agricultural applications.
蛇床子素是一种从……中分离出的天然香豆素类化合物。在过去几年中，这种植物源产品及其衍生物因其有趣的生物活性，包括抗癌、抗炎、神经保护和杀虫作用而备受关注。本综述总结了2018年至2025年初蛇床子素及其衍生物生物活性的最新进展，重点关注其全合成、结构修饰和作用机制。此外，还介绍了蛇床子素衍生物的构效关系（SARs）。本综述旨在为蛇床子素及其衍生物在医药和农业应用方面的未来研究提供全面参考。
