Jaeger P, Portmann L, Wauters J P, Hürlimann J, Bill G, Scazziga B, Burckhardt P
Am J Nephrol. 1985;5(2):116-20. doi: 10.1159/000166923.
In a 33-year-old woman concurrence of a complete distal renal tubular acidosis (RTA) and lymphocytic thyroiditis with spontaneously resolving hyperthyroidism was observed. Until recently, the rare association of RTA and hyperthyroidism had been thought to be governed by nephrocalcinosis, via hypercalcemia and hypercalciuria. However, in this case, nephrocalcinosis was not present, but there were histological signs of renal interstitial mononuclear cell infiltration, and the RTA persisted despite the resolution of the hyperthyroidism. This observation supports the idea that immunological mechanisms may relate RTA and hyperthyroidism when the latter has an autoimmune origin.
在一名33岁女性中，观察到完全性远端肾小管酸中毒（RTA）与淋巴细胞性甲状腺炎并发，并伴有自发缓解的甲状腺功能亢进。直到最近，RTA与甲状腺功能亢进的罕见关联一直被认为是由肾钙质沉着症通过高钙血症和高钙尿症介导的。然而，在该病例中，不存在肾钙质沉着症，但有肾间质单核细胞浸润的组织学迹象，并且尽管甲状腺功能亢进已缓解，但RTA仍然持续存在。这一观察结果支持了这样一种观点，即当甲状腺功能亢进具有自身免疫起源时，免疫机制可能与RTA和甲状腺功能亢进有关。
