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动脉高血压与认知障碍之间的关系:文献综述

The Relation Between Arterial Hypertension and Cognitive Impairment: A Literature Review.

作者信息

Zúñiga Salazar Gabriel, Zúñiga Diego, Balasubramanian Sneha, Mehmood Khawar Tariq, Al-Baldawi Shahad

机构信息

Medicine, Universidad Católica de Santiago de Guayaquil, Guayaquil, ECU.

Internal Medicine, Madras Medical College, Chennai, IND.

出版信息

Cureus. 2024 Jan 23;16(1):e52782. doi: 10.7759/cureus.52782. eCollection 2024 Jan.

Abstract

The global increase in dementia cases, driven by improved life expectancy and reduced elderly mortality rates, presents a significant public health challenge. Dementia, characterized by a gradual and irreversible decline in cognitive abilities, affects individuals aged 65 and older, disrupting lives and straining healthcare systems. Hypertension significantly influences dementia development. Research consistently links midlife hypertension to cognitive decline, mild cognitive impairment (MCI), and dementia, but findings in older adults vary. While some studies suggest that late-life hypertension accelerates cognitive decline and dementia risk, others propose a protective effect. The impact of hypertension on cognition varies across age groups, spanning from childhood to late life. High blood pressure during midlife and earlier life stages consistently predicts poorer cognitive outcomes. Executive function, attention, and motor speed are the cognitive domains most affected by hypertension, particularly in subcortical diseases. Memory impairments in hypertension-related dementias are complex, often overlapping with other causes. Understanding the inconsistent findings in older adults regarding hypertension, cognitive decline, and dementia risk requires comprehensive exploration of methodological and biological factors. Addressing hypertension and its management may hold the key to reducing the risk of cognitive decline and dementia, especially in midlife and earlier life stages.

摘要

随着预期寿命的延长和老年死亡率的降低,全球痴呆症病例不断增加,这给公共卫生带来了重大挑战。痴呆症的特征是认知能力逐渐且不可逆转地下降,影响65岁及以上的人群,扰乱他们的生活并给医疗系统带来压力。高血压对痴呆症的发展有重大影响。研究一直将中年高血压与认知能力下降、轻度认知障碍(MCI)和痴呆症联系起来,但关于老年人的研究结果却各不相同。虽然一些研究表明老年高血压会加速认知能力下降和患痴呆症的风险,但另一些研究则提出了保护作用。高血压对认知的影响在从童年到老年的各个年龄组中有所不同。中年和更早生命阶段的高血压一直预示着较差的认知结果。执行功能、注意力和运动速度是受高血压影响最大的认知领域,尤其是在皮质下疾病中。高血压相关痴呆症中的记忆障碍很复杂,常常与其他原因重叠。要理解老年人在高血压、认知能力下降和痴呆症风险方面不一致的研究结果,需要全面探讨方法学和生物学因素。控制高血压及其管理可能是降低认知能力下降和痴呆症风险的关键,尤其是在中年和更早生命阶段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d1a3/10882260/0950d2e0be74/cureus-0016-00000052782-i01.jpg

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