西咪替丁、氢氧化铝和牛奶对阿莫西林生物利用度的影响。
Augmentin bioavailability following cimetidine, aluminum hydroxide and milk.
作者信息
Staniforth D H, Clarke H L, Horton R, Jackson D, Lau D
出版信息
Int J Clin Pharmacol Ther Toxicol. 1985 Mar;23(3):154-7.
PMID:3838971
Abstract
Previous studies [Jackson et al. 1980] have shown that the bioavailability of Augmentin is not affected by food. The present work has shown that aluminum hydroxide, milk and cimetidine do have some influence on the bioavailability of a single dose of oral Augmentin, but the small differences observed are unlikely to be of therapeutic importance. It is concluded that Augmentin may be administered in clinical practice with any of these substances.
摘要
先前的研究[杰克逊等人，1980年]表明，阿莫西林克拉维酸钾的生物利用度不受食物影响。目前的研究表明，氢氧化铝、牛奶和西咪替丁确实对单剂量口服阿莫西林克拉维酸钾的生物利用度有一定影响，但观察到的微小差异不太可能具有治疗意义。结论是，在临床实践中，阿莫西林克拉维酸钾可与这些物质中的任何一种一起给药。
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