Lund-Olesen K
Int J Clin Pharmacol Res. 1985;5(1):59-62.
During the period 1971-78, 133 intrathecal injections of orgotein or superoxide dismutase have been given, mostly to patients with multiple sclerosis. Evaluation of the effect was deficient but the impression was that of improvement and 45% of the 58 patients with multiple sclerosis requested further intrathecal injections. In one case, intrathecal injections had a good effect against allergic headaches after myelography. Determination of orgotein in samples of cerebrospinal fluid from 16 patients with multiple sclerosis gave remarkable results in that the content of orgotein was significantly lower than the level reported by other investigators.
在1971年至1978年期间，共进行了133次鞘内注射奥古蛋白或超氧化物歧化酶，大多数注射对象是多发性硬化症患者。对疗效的评估并不充分，但总体印象是病情有所改善，58例多发性硬化症患者中有45%要求进一步进行鞘内注射。有1例患者在脊髓造影后鞘内注射对过敏性头痛有良好效果。对16例多发性硬化症患者脑脊液样本中的奥古蛋白进行测定，结果显著，即奥古蛋白含量明显低于其他研究者报告的水平。
