Wagner A E, McIlwraith C W, Martin G S
Am J Vet Res. 1982 Apr;43(4):594-7.
Orgotein was injected into the right intercarpal joint of each of 8 horses; the corresponding left joint was left alone (not injected) or was given an injection of normal saline solution. Injection with orgotein caused a transient, marked inflammatory response, evidenced by clinical signs and by increased leukocytes and total protein in the synovia (synovial fluid). Leukocyte numbers and total protein concentration were increased (P less than 0.010) in the orgotein-injected joints within 24 hours. However, saline solution alone also elicited a marked inflammatory response, manifested by increased leukocyte count and total protein concentration. By 7 days, leukocyte and total protein values had returned to approximately base line in all joints.
将奥古蛋白注射到8匹马每匹马的右腕骨间关节；相应的左关节不做处理（不注射）或注射生理盐水。注射奥古蛋白引发了短暂的、明显的炎症反应，临床症状以及滑液中白细胞和总蛋白增加都证明了这一点。注射奥古蛋白的关节在24小时内白细胞数量和总蛋白浓度增加（P小于0.010）。然而，仅注射生理盐水也引发了明显的炎症反应，表现为白细胞计数和总蛋白浓度增加。到第7天，所有关节的白细胞和总蛋白值已恢复到大致基线水平。
