Seĭtkazina G D, Efimov M L, Koposova R P
Med Radiol (Mosk). 1985 May;30(5):73-5.
A study was made of metronidazole accumulation in the blood of animals and tumorous tissues of Pliss lymphosarcoma after the total moderate hyperthermia caused by subcutaneous injection of the pyrogenic drug sulfadiazine. Metronidazole concentration in the blood and tumors of hyperthermized animals was 2-3 times as high as in those of the control animals. A time shift of the maximum values of metronidazole accumulation occurred in hyperthermia. Under normal conditions the peak of accumulation was observed 2 h after the administration of the radiosensitizer whereas in hyperthermia depending on its duration it could develop 1 h earlier. Thus the total moderate hyperthermia served as a favorable background for raising metronidazole concentration in tumor opening up prospects for potentiating the radiosensitizing effect of metronidazole and perhaps some other means in the utilization of small nontoxic doses of the drug.
研究了皮下注射致热药物磺胺嘧啶引起全身中度热疗后，甲硝唑在动物血液和普利斯淋巴肉瘤肿瘤组织中的蓄积情况。热疗动物血液和肿瘤中的甲硝唑浓度是对照动物的2至3倍。热疗时甲硝唑蓄积的最大值出现时间有变化。正常情况下，给予放射增敏剂2小时后观察到蓄积峰值，而在热疗时，根据热疗持续时间，峰值可能提前1小时出现。因此，全身中度热疗为提高肿瘤中甲硝唑浓度创造了有利条件，为增强甲硝唑的放射增敏作用以及可能利用小剂量无毒药物的其他方法开辟了前景。
